| AL cardiac amyloidosis and arterial thromboembolic events. | |
| | |
MedLine Citation:
|
PMID: 16195166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the prevalence and characteristics of arterial thromboembolic events (ATEE) in the course of AL amyloidosis. METHODS: We report the case of a non-anticoagulated patient with AL amyloidosis restrictive cardiomyopathy who developed acute lower limb ischaemia. We then prospectively determined the prevalence of ATEE in all patients with AL amyloidosis who were evaluated in our institution for autologous peripheral stem cell transplantation. RESULTS: Nine out of 15 non-anticoagulated patients (60%) developed ATEE: ischaemic stroke (3), transient cerebral ischaemic attack (2), multiple peripheral arterial emboli (1), bilateral iliac artery thrombosis (1), bilateral optic nerve ischaemia (1), and mesenteric ischaemia (1). Haemodynamic stasis seemed to play a leading role in the pathophysiology of ATEE, in that all patients were on sinus rhythm and only one had a thrombus on echocardiography. We identified possible contributing factors to ATEE occurrence: concomitant treatments with oestroprogestogen regimen, thalidomide, granulocyte-macrophage colony-stimulating factor (GM-CSF) and extracellular volume disturbances related to the cytapheresis procedure. CONCLUSION: We report on an unusual frequency of ATEE among patients with AL cardiac amyloidosis. Despite its theoretical risks, anticoagulation should be discussed for patients with amyloid cardiomyopathy. |
| | |
Authors:
|
P Hausfater; N Costedoat-Chalumeau; Z Amoura; P Cacoub; T Papo; G Grateau; V Leblond; P Godeau; J C Piette |
Related Documents
:
|
3628126 - Brain cardioembolism. issues in diagnosis and management. 16516596 - Adherence to american college of cardiology/american heart association guidelines for t... 11128796 - A complication in anticoagulation using low-molecular weight heparin in a patient with ... 15570646 - Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gout... 10423106 - Summary of randomized trials of angiotensin converting enzyme inhibitors. 6883926 - Control of skeletal muscle blood flow during postural changes in acute myocardial infar... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Scandinavian journal of rheumatology Volume: 34 ISSN: 0300-9742 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 2005 Jul-Aug |
Date Detail:
|
Created Date: 2005-09-30 Completed Date: 2005-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: Norway |
Other Details:
|
Languages: eng Pagination: 315-9 Citation Subset: IM |
Affiliation:
|
Emergency Department, Pitie-Salpetriere University Hospital Centre, 75651 Paris Cedex 13, France. pierre.hausfater@psl.ap-hop-paris.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Amyloidosis / complications, diagnosis*, therapy Angiography / methods Arterial Occlusive Diseases / complications, radiography, surgery* Cardiomyopathies / complications, diagnosis*, therapy Disease Progression Embolectomy / methods Fatal Outcome Female Femoral Artery* Heart Failure / diagnosis* Humans Risk Assessment |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Muscle hypertrophy, strength development, and serum hormones during strength training in elderly wom...
Next Document: EBV-associated haemophagocytic syndrome in a patient with Behçet's disease.