Document Detail


AIP1 in graft arteriosclerosis.
MedLine Citation:
PMID:  22902071     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Graft arteriosclerosis (GA), the major cause of late cardiac allograft failure, is characterized by a diffuse, concentric arterial intimal hyperplasia composed of infiltrating host T cells, macrophages, and predominantly graft-derived smooth muscle-like cells that proliferate and elaborate extracellular matrix, resulting in luminal obstruction and allograft ischemia. Interferon-γ (IFN-γ), a proinflammatory cytokine produced by effector T cells, is a critical mediator for smooth muscle-like cell proliferation. We have exploited the power of mouse genetics to examine the function of AIP1, a signaling adaptor molecule involved in vascular inflammation, in two newly established IFN-γ-mediated models of GA. Our data suggest that AIP1 inhibits intimal formation in GA by downregulating IFN-γ-activated migratory and proliferative signaling pathways in smooth muscle-like cells.
Authors:
Wang Min; Jordan S Pober
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Interdepartmental Program in Vascular Biology and Therapeutics and the Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. wang.min@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Cell Proliferation
Coronary Artery Disease / etiology,  immunology,  metabolism*,  pathology
Disease Models, Animal
Heart Transplantation / adverse effects*
Humans
Interferon-gamma / metabolism
Mice
Muscle, Smooth, Vascular / immunology,  metabolism*,  pathology
Neointima
ras GTPase-Activating Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
R01 HL065978/HL/NHLBI NIH HHS; R01 HL109420/HL/NHLBI NIH HHS; R01 HL109420/HL/NHLBI NIH HHS; R01 HL109455/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/DAB2IP protein, human; 0/Dab2ip protein, mouse; 0/ras GTPase-Activating Proteins; 82115-62-6/Interferon-gamma
Comments/Corrections

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