| AIMing 2 detect foreign DNA. | |
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MedLine Citation:
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PMID: 19567913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Foreign genomic DNA can be detected by immune cells in the cytoplasm, triggering reactions such as cell death and secretion of proinflammatory cytokines, including interleukin 1beta (IL-1beta). Several studies have now elucidated the mechanism for this response. The HIN-200 (hematopoietic interferon-inducible nuclear proteins with a 200-amino acid repeat) family member AIM2 (absent in melanoma 2) binds and oligomerizes on cytoplasmic DNA through a HIN domain. The oligomerized AIM2 recruits the adaptor ASC (apoptosis-associated specklike protein containing a CARD) through homotypic pyrin domain interactions and binds caspase-1, forming an inflammasome that generates IL-1beta. Together with previous studies, this work demonstrates that immune detection of foreign nucleic acids occurs through several distinct signaling pathways, leading to diverse immune outcomes. |
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Authors:
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Arthur M Krieg |
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Publication Detail:
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Type: Journal Article Date: 2009-06-30 |
Journal Detail:
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Title: Science signaling Volume: 2 ISSN: 1937-9145 ISO Abbreviation: - Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-01 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101465400 Medline TA: Sci Signal Country: United States |
Other Details:
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Languages: eng Pagination: pe39 Citation Subset: IM |
Affiliation:
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Pfizer Research Technology Center, 620 Memorial Drive, Cambridge, MA 02139, USA. arthur.krieg@pfizer.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopolymers
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chemistry,
metabolism DNA / chemistry, metabolism* Nuclear Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/AIM2 protein, human; 0/Biopolymers; 0/Nuclear Proteins; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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