Document Detail


AIDS-related MR hyperintensity of the basal ganglia.
MedLine Citation:
PMID:  9432162     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Our goal was to describe the MR imaging appearance and clinical pathologic correlates of bilateral basal ganglia hyperintensity in acquired immunodeficiency syndrome (AIDS). METHODS: Medical records and laboratory data were reviewed retrospectively in nine cases of bilateral basal ganglia hyperintensity on long-repetition-time MR images. Opportunistic infections of the central nervous system were excluded by clinical and laboratory data. Postmortem neuropathologic examination was obtained in two cases. RESULTS: All patients presented acutely with new seizures or changes in mental status. A history of drug abuse was elicited in seven of the nine remaining patients. Renal failure was present in six cases. Symmetric bilateral caudate and putamen hyperintensity on T2-weighted images was found in all cases with variable extension to the surrounding white matter, thalamus, and brain stem. Postmortem neuropathologic examination in two cases revealed numerous microinfarcts in a distribution similar to the MR signal abnormalities. CONCLUSION: The MR appearance of basal ganglia hyperintensity in this series of AIDS patients represents ischemic tissue injury. We propose that this clinicopathologic entity is precipitated by the combined effects of human immunodeficiency virus infection and drug use, particularly cocaine and/or associated toxic contaminants.
Authors:
C C Meltzer; S W Wells; M W Becher; K M Flanigan; G A Oyler; R R Lee
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  19     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-20     Completed Date:  1998-03-20     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM; X    
Affiliation:
Department of Radiology, University of Pittsburgh Medical Center, Pa 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS Dementia Complex / diagnosis*,  pathology
Adult
Basal Ganglia / pathology*
Cocaine
Female
Humans
Magnetic Resonance Imaging*
Male
Retrospective Studies
Substance-Related Disorders
Chemical
Reg. No./Substance:
50-36-2/Cocaine

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