| AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz. | |
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MedLine Citation:
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PMID: 20696916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the absence of treatment, most HIV-1-infected humans develop AIDS. However, a minority are long-term nonprogressors, and resistance is associated with the presence of particular HLA-B*27/B*57 molecules. In contrast, most HIV-1-infected chimpanzees do not contract AIDS. In comparison with humans, chimpanzees experienced an ancient selective sweep affecting the MHC class I repertoire. We have determined the peptide-binding properties of frequent chimpanzee MHC class I molecules, and show that, like HLA-B*27/B*57, they target similar conserved areas of HIV-1/SIV(cpz). In addition, many animals appear to possess multiple molecules targeting various conserved areas of the HIV-1/SIV(cpz) Gag protein, a quantitative aspect of the immune response that may further minimize the chance of viral escape. The functional characteristics of the contemporary chimpanzee MHC repertoire suggest that the selective sweep was caused by a lentiviral pandemic. |
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Authors:
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Natasja G de Groot; Corrine M C Heijmans; Yvonne M Zoet; Arnoud H de Ru; Frank A Verreck; Peter A van Veelen; Jan W Drijfhout; Gaby G M Doxiadis; Edmond J Remarque; Ilias I N Doxiadis; Jon J van Rood; Frits Koning; Ronald E Bontrop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-09 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 15175-80 Citation Subset: IM |
Affiliation:
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Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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genetics,
immunology,
prevention & control* Amino Acid Sequence Animals Cell Line Conserved Sequence Gene Products, gag / genetics, metabolism Genes, MHC Class I HIV Long-Term Survivors HIV-1 / genetics*, immunology* HLA-B Antigens / genetics* HLA-B27 Antigen / genetics* Histocompatibility Antigens Class I / genetics* Humans Molecular Sequence Data Pan troglodytes / genetics*, immunology* Protein Binding Simian immunodeficiency virus / genetics*, immunology* Species Specificity T-Lymphocytes, Cytotoxic / immunology |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, gag; 0/HLA-B Antigens; 0/HLA-B27 Antigen; 0/HLA-B57; 0/Histocompatibility Antigens Class I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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