| AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules. | |
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MedLine Citation:
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PMID: 8798974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human immunodeficiency virus (HIV) causes in humans the acquired immunodeficiency syndrome (AIDS). It replicates at a high rate in lymphoid organs even before it causes clinical symptoms. It binds to CD4 cell surface markers and destroys T lymphocytes that express the receptor. The immune system replenishes CD4 T cells at a formidable rate but, unable to keep up with the losses, allows the CD4 T cell compartment to disintegrate gradually. The net loss of CD4 T cells is an indicator for disease progression. How the virus destroys CD4 T cells and whether their loss accounts for the ensuing immunodeficiency have not been fully explained. We have reported evidence, and confirm here, that HIV-infected subjects deposit on monocytes immune complexes containing the virus or its envelope molecule gp120. Armed with these immune complexes monocytes form specific cellular conjugates with CD4 T cells and kill them. The destruction of normal CD4 T cells by monocytes from AIDS patients can be blocked by soluble CD4 and by free gp120. Normal monocytes and macrophages can be armed with CD4-binding gp120, and so induced to destroy CD4 T cells, by incubating them with gp120 and gp120-specific antibody. CD4-reactive HIV-1 components have a short half-life on the phagocyte surface. Removed from the HIV-infected environment, monocytes clear their surfaces of antibody-complexed viral components within hours, which abrogates their ability to destroy CD4 T cells. Rearming the monocytes with gp120-anti-gp120 complexes restores their capacity to destroy CD4 T cells. The data imply that for uninterrupted deletion of CD4 T cells, monocytes require a continued productive HIV-1 infection of their host. |
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Authors:
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A Dudhane; Z Q Wang; T Orlikowsky; A Gupta; G P Wormser; H Horowitz; P Kufer; M K Hoffmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 12 ISSN: 0889-2229 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 893-9 Citation Subset: IM; X |
Affiliation:
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Department of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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blood,
immunology* Adult Antigen-Antibody Complex / immunology Antigens, CD4 / immunology* CD4-Positive T-Lymphocytes / immunology* Clonal Deletion* HIV Envelope Protein gp120 / immunology* Humans Monocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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5 RO1AI29869/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Antigens, CD4; 0/HIV Envelope Protein gp120 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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