Document Detail

AIDS-associated non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy.
MedLine Citation:
PMID:  10430215     Owner:  NLM     Status:  MEDLINE    
In populations receiving highly active antiretroviral therapy (HAART), the incidence of non-Hodgkin's lymphoma (NHL) has decreased by less than other AIDS-associated illnesses. In Australian AIDS-registration data, NHL has decreased by 37.5% since 1994, compared with a 55% decrease for other AIDS-associated illnesses (p = .033). Three factors may contribute to this discrepancy. First, in contrast to most other AIDS-associated illness, molecular and epidemiologic evidence suggests that there is no single organism that causes AIDS-related NHL. Thus, the HAART-induced partial recovery of reactivity to foreign antigens may be relatively ineffective in NHL prevention. Second, with the exception of primary NHL of the central nervous system, AIDS-related NHL tends to occur at a less advanced stage of immune deficiency than other AIDS-related diseases; therefore, the HAART-associated partial recovery of the immune system may be insufficient to prevent NHL. Third, it is unclear whether HAART is fully effective at reversing the B-cell stimulation that is associated with HIV infection and is a risk factor for NHL. Unless more complete immune reconstitution can be achieved, it is likely that NHL will become proportionately more important as a cause of morbidity and mortality in people with HIV and AIDS.
A E Grulich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  21 Suppl 1     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-24     Completed Date:  1999-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S27-30     Citation Subset:  IM; X    
National Centre in HIV Epidemiology and Clinical Research, Sydney, New South Wales, Australia.
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MeSH Terms
AIDS-Related Opportunistic Infections / drug therapy,  epidemiology*,  immunology
Anti-HIV Agents* / administration & dosage
B-Lymphocytes / drug effects,  immunology
Lymphoma, AIDS-Related / epidemiology*
Lymphoma, Non-Hodgkin / epidemiology*
Reg. No./Substance:
0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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