| AID: a riddle wrapped in a mystery inside an enigma. | |
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MedLine Citation:
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PMID: 21128007 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To combat the ever-changing pool of pathogens we face, B cells generate highly optimized antibodies in two distinct steps. A large variety of antibodies are first generated randomly by V(D)J recombination, and then, upon encountering an antigen, antibodies are fine-tuned by somatic hypermutation and class switch recombination-both of which are initiated by the same protein, activation-induced cytidine deaminase (AID). All three processes are highly mutagenic, and mistargeting of each of these has been shown to contribute to tumorigenesis. We study these processes because they provide an excellent model to understand how highly mutagenic reactions are channeled into productive use by cells and the consequent risk this carries. In this review, we will discuss many of the outstanding questions in the field that we grapple with while developing a consistent model for AID action. We will also discuss the complexity added to these models by the recent finding that AID might be part of a demethylase complex. |
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Authors:
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Dana C Upton; Briana L Gregory; Rahul Arya; Shyam Unniraman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunologic research Volume: 49 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 14-24 Citation Subset: IM |
Affiliation:
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Department of Immunology, Duke University, 312 Edwin L. Jones Bldg., Campus Box # 3010, Durham, NC, 27710, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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