| AID-mediated somatic hypermutation for generation of viral envelope protein diversity in patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies. | |
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MedLine Citation:
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PMID: 19917313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The somatic hypermutation (SHM) hypothesis for R5-X4 HIV-1 switching has recently received experimental support. AID-mediated SHM in B cell lines can be used to generate patient's HIV-1 envelope protein diversity in vitro for subsequent vaccination of HIV-1-infected patient at the beginning of asymptomatic period with a resulting mixture of mutant envelope proteins. Suggested approach, which represents a vaccination against R5-X4 HIV-1 switching, might open possibilities for creation of patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies. |
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Authors:
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Konstantin V Suslov |
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Publication Detail:
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Type: Letter Date: 2009-11-14 |
Journal Detail:
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Title: Immunology letters Volume: 128 ISSN: 1879-0542 ISO Abbreviation: Immunol. Lett. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 86-7 Citation Subset: IM |
Affiliation:
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Russian State Medical University, 1 Ostrovityanov St, Moscow 117 997, Russia. suslov_kv@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Vaccines* Acquired Immunodeficiency Syndrome / drug therapy*, immunology* Antibodies, Neutralizing* Antigenic Variation B-Lymphocytes / immunology, metabolism Cell Line Epitopes / immunology HIV Envelope Protein gp120 / immunology HIV-1 / immunology*, pathogenicity Humans Mutant Proteins / immunology Somatic Hypermutation, Immunoglobulin |
| Chemical | |
Reg. No./Substance:
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0/AIDS Vaccines; 0/Antibodies, Neutralizing; 0/Epitopes; 0/HIV Envelope Protein gp120; 0/Mutant Proteins |
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