Document Detail


AHR-5850: a potent anti-inflammatory compound.
MedLine Citation:
PMID:  871089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AHR-5850 is a non-steroidal anti-inflammatory compound possessing antipyretic and analgesic properties. AHR-5850 was 16.4 and 22.8 times more potent than phenylbutazone in suppressing acute (Evans blue-carrageenan pleural effusion) and chronic (adjuvant-induced arthritis) inflammation, respectively. The analgesic activity of AHR 5850 was 43 times that of acetylsalicylic acid in the Randall-Selitto assay, and 156 and 56.3 times more potent than phenylbutazone in the acetylcholine-induced abdominal constriction in mice and in the bradykinin-induced nociceptive response in dogs, respectively. Single-dose studies showed that AHR-5850 produced less gastric irritation than acetylsalicylic acid when applied topically to the exposed gastric mucosa of cats or when administered orally to rats and dogs. Upon subchronic oral administration to rats, the therapeutic ratio of AHR-5850 was twice that of phenylbutazone. This was based on the ratio of its potency relative to phenylbutazone in producing intestinal lesions to its anti-inflammatory potency relative to phenylbutazone in the adjuvant-induced arthritis.
Authors:
L F Sancilio; D L Reese; S Cheung; R S Alphin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Agents and actions     Volume:  7     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  133-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Benzophenones / therapeutic use*
Blood Glucose / metabolism
Cats
Chronic Disease
Dogs
Drug Evaluation, Preclinical
Edema / drug therapy
Female
Gastric Mucosa / drug effects
Male
Mice
Phenylacetates / therapeutic use*
Rats
Species Specificity
Tolbutamide / pharmacology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Benzophenones; 0/Blood Glucose; 0/Phenylacetates; 64-77-7/Tolbutamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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