Document Detail


AGT and RH blood group polymorphisms affect blood pressure and lipids in Afro-Caribbeans.
MedLine Citation:
PMID:  14961043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Population blood pressure variation is most likely due to multiple genes. This is likely the reason why monogenic testing with the angiotensinogen (AGT) gene polymorphisms on chromosome 1 (1q42-43), especially M235T, has met with negative results, especially in those of African descent. The RH blood group system, also on chromosome 1 (1 p36.2-34), has likewise been associated with blood pressure variation in African-Americans and with the rise in blood pressure with age in whites. Using a random sample of the population, we investigated the combined effects of single and combined variation of the AGTN M235T and RH genotypes on blood pressure, lipids, and lipoprotein concentrations in Afro-Caribbeans aged 18-60 years from the island nation of Dominica. In monogenic analysis, AGT M235T was not associated with blood pressure. However, it was associated with HDL (MM 42+/-23, MT 44+/-12, TT 52+/-14 (P=0.002)). RH genotype was significantly associated with systolic blood pressure (P=0.006) and Apo-A (P=0.003). These effects remained after adjustment for age, gender, weight, and BMI. In the polygenetic analysis, AGT M235T and RH were significantly associated with systolic blood pressure (P=0.037; interaction effects, P=0.068). The association of the AGT M235T with blood pressure across RH blood group haplotypes was then tested. Of the five RH haplotypes available for analysis, the AGT M235T was significantly associated with blood pressure within the "D" haplotype (P=0.01). The RH blood group and gender were significantly associated with systolic blood pressure and Apo-A levels (P=0.005 and 0.012, respectively). All interactions were independent of age and weight. In conclusion, we demonstrate a significant association of AGT M235T with blood pressure and cholesterol metabolism in an Afro-Caribbean population in the "genetic context" of the RH blood group system. Further investigation of these interactions may help understand the effects of genetic factors on cardiovascular risk in African-derived and other populations.
Authors:
M T Robinson; T W Wilson; G A Nicholson; G A C Grell; C Etienne; C M Grim; D Wilson; C E Grim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2004-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-63     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, UC San Diego, La Jolla, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Angiotensinogen / genetics*
Blood Pressure / genetics*
Cardiovascular Diseases / etiology
Caribbean Region
Demography
Female
Genotype
Haplotypes
Humans
Lipids / blood*
Male
Methionine
Middle Aged
Polymorphism, Genetic*
Rh-Hr Blood-Group System / genetics*
Risk Factors
Threonine
Grant Support
ID/Acronym/Agency:
4HL-01885/HL/NHLBI NIH HHS; G12RR-03026/RR/NCRR NIH HHS; RR03026/RR/NCRR NIH HHS; T32M-HL07655/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Rh-Hr Blood-Group System; 11002-13-4/Angiotensinogen; 63-68-3/Methionine; 72-19-5/Threonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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