| AFM membrane roughness as a probe to identify oxidative stress-induced cellular apoptosis. | |
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MedLine Citation:
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PMID: 21937047 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The morphological change of cellular apoptosis initiates from the change of membrane roughness. In order to identify cellular apoptosis in its early stage, atomic force microscope was adapted to reveal the change of membrane roughness in unprecedented details, providing an image in nanometer-scaled resolution. The mouse monocyte/macrophage cell line RAW 264.7 was the subject studied and subjected to apoptotic induction by hydrogen peroxide. A finding of the qualitative correlation between cell membrane roughness and oxidative stress level is disclosed stating that roughness is increasing with the increasing level of oxidative stress. |
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Authors:
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Dau-Chung Wang; Ken-Yen Chen; Cheng-Hsien Tsai; Gen-You Chen; Chuan-Hung Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-19 |
Journal Detail:
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Title: Journal of biomechanics Volume: - ISSN: 1873-2380 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Mechanical Engineering, National Yunlin University of Science and Technology, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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