Document Detail


ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis.
MedLine Citation:
PMID:  15153795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The beta(2)-adrenergic receptor (ADRB2) is the most common adrenergic receptor in the lung, and associations between ADRB2 polymorphisms and intermediate phenotypes of asthma have been reported. Four missense polymorphisms (Arg16Gly, Gln27Glu, Val34Met, and Thr164Ile) and one polymorphism in the 5' leader cistron of the ADRB2 messenger RNA has been identified. In vitro studies have shown that these missense polymorphisms can affect ADRB2 function. METHODS: To examine possible associations of ADRB2 polymorphisms with asthma susceptibility, we performed transmission disequilibrium tests (TDT) of 137 Japanese families identified through children with atopic asthma. RESULTS: We did not find associations between any alleles of the ADRB2 polymorphisms and asthma by TDT (p > 0.1). We also performed a meta-analysis of data from all available studies. The random-effects model showed no significant odds ratio for the Arg16Gln (odds ratio = 1.05, p = 0.53) or Gln27Glu (odds ratio = 1.12, p = 0.22) polymorphism. CONCLUSION: Our data indicate that ADRB2 does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with asthma.
Authors:
Ohsuke Migita; Emiko Noguchi; Zhang Jian; Masanao Shibasaki; Takuo Migita; Kunio Ichikawa; Akira Matsui; Tadao Arinami
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2004-05-19
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  134     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-04     Completed Date:  2004-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Affiliation:
Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Asthma / genetics*
Child
Child, Preschool
Family Health
Female
Genetic Predisposition to Disease / genetics
Genotype
Humans
Japan / epidemiology
Linkage Disequilibrium / genetics
Male
Middle Aged
Polymorphism, Genetic / genetics*
Receptors, Adrenergic, beta-2 / genetics*
Sensitivity and Specificity
Statistics as Topic
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2

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