Document Detail


ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent.
MedLine Citation:
PMID:  20727557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Classic tissue effects of β(2)-adrenergic receptor activation include skeletal muscle glycogenolysis and vascular smooth muscle relaxation, factors relevant to obesity and hypertension, respectively. In a population-based study, we examined 2 common amino acid substitutions in the β(2)-adrenergic receptor gene (ADRB2) in relation to body composition and blood pressure. A cross-sectional analysis of 1893 African-descent men living in Tobago and participating in a prostate cancer screening study was performed. Body mass index, waist circumference, blood pressure, dual-energy x-ray absorptiometry body composition, and ADRB2 (Arg16Gly; Gln27Glu) genotype were determined. Twenty-six percent were obese (body mass index ≥30 kg/m(2)), and 50% were hypertensive. ADRB2 Arg16Gly and Gln27Glu alleles were in linkage disequilibrium (D' = 0.96, r(2) = 0.15). ADRB2 16Gly-containing and 27Glu-containing genotypes were equally frequent in low, medium, and high tertiles of percentage of body fat mass (16Gly-containing genotypes: 73.4%, 74.4%, and 74.5%, P(trend) = .66; 27Glu-containing genotypes: 27.6%, 23.8%, and 25.4%, P(trend) = .39) and in normal blood pressure, prehypertensive, and hypertensive men (16Gly-containing genotypes: 73.4%, 72.8%, and 74.4%, P(trend) = .61; 27Glu-containing genotypes: 25.6%, 24.1%, and 26.7%, P(trend) = .50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension.
Authors:
Tracey Samantha Beason; Clareann H Bunker; Joseph M Zmuda; John W Wilson; Alan L Patrick; Victor W Wheeler; Joel L Weissfeld
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-19
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  60     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-07-11     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-705     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
African Continental Ancestry Group / genetics*
Aged
Blood Pressure / genetics
Body Composition / genetics*
Body Mass Index
Cross-Sectional Studies
Humans
Hypertension / genetics*
Linkage Disequilibrium
Male
Middle Aged
Obesity / epidemiology,  genetics
Polymorphism, Genetic
Receptors, Adrenergic, beta-2 / genetics*
Trinidad and Tobago / epidemiology
Waist Circumference / genetics
Grant Support
ID/Acronym/Agency:
R01 AR049747/AR/NIAMS NIH HHS; R01 AR049747-05/AR/NIAMS NIH HHS; R01 CA084950-10S1/CA/NCI NIH HHS; R01-AR049747/AR/NIAMS NIH HHS; R01-CA84950/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/ADRB2 protein, human; 0/Receptors, Adrenergic, beta-2
Comments/Corrections

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