| ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descent. | |
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MedLine Citation:
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PMID: 20727557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Classic tissue effects of β(2)-adrenergic receptor activation include skeletal muscle glycogenolysis and vascular smooth muscle relaxation, factors relevant to obesity and hypertension, respectively. In a population-based study, we examined 2 common amino acid substitutions in the β(2)-adrenergic receptor gene (ADRB2) in relation to body composition and blood pressure. A cross-sectional analysis of 1893 African-descent men living in Tobago and participating in a prostate cancer screening study was performed. Body mass index, waist circumference, blood pressure, dual-energy x-ray absorptiometry body composition, and ADRB2 (Arg16Gly; Gln27Glu) genotype were determined. Twenty-six percent were obese (body mass index ≥30 kg/m(2)), and 50% were hypertensive. ADRB2 Arg16Gly and Gln27Glu alleles were in linkage disequilibrium (D' = 0.96, r(2) = 0.15). ADRB2 16Gly-containing and 27Glu-containing genotypes were equally frequent in low, medium, and high tertiles of percentage of body fat mass (16Gly-containing genotypes: 73.4%, 74.4%, and 74.5%, P(trend) = .66; 27Glu-containing genotypes: 27.6%, 23.8%, and 25.4%, P(trend) = .39) and in normal blood pressure, prehypertensive, and hypertensive men (16Gly-containing genotypes: 73.4%, 72.8%, and 74.4%, P(trend) = .61; 27Glu-containing genotypes: 25.6%, 24.1%, and 26.7%, P(trend) = .50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension. |
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Authors:
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Tracey Samantha Beason; Clareann H Bunker; Joseph M Zmuda; John W Wilson; Alan L Patrick; Victor W Wheeler; Joel L Weissfeld |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-19 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 60 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-19 Completed Date: 2011-07-11 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 698-705 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult African Continental Ancestry Group / genetics* Aged Blood Pressure / genetics Body Composition / genetics* Body Mass Index Cross-Sectional Studies Humans Hypertension / genetics* Linkage Disequilibrium Male Middle Aged Obesity / epidemiology, genetics Polymorphism, Genetic Receptors, Adrenergic, beta-2 / genetics* Trinidad and Tobago / epidemiology Waist Circumference / genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR049747-05/AR/NIAMS NIH HHS; R01 CA084950-10S1/CA/NCI NIH HHS; R01-AR049747/AR/NIAMS NIH HHS; R01-CA84950/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ADRB2 protein, human; 0/Receptors, Adrenergic, beta-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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