| ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. | |
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MedLine Citation:
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PMID: 7805847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human BST-1, a bone marrow stromal cell surface molecule, is a GPI-anchored protein that facilitates the growth of pre-B cells. The deduced amino acid sequences of human and mouse BST-1 show around 30% homology with those of CD38 and Aplysia ADP ribosyl cyclase. Therefore, like CD38, BST-1 might possess ADP ribosyl cyclase activity. Here, we report the establishment of a stable transformant CHO cell line, which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase and cADPR hydrolase activities. |
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Authors:
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Y Hirata; N Kimura; K Sato; Y Ohsugi; S Takasawa; H Okamoto; J Ishikawa; T Kaisho; K Ishihara; T Hirano |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 356 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-27 Completed Date: 1995-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 244-8 Citation Subset: IM |
Affiliation:
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Fuji Gotemba Research Labs. Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADP-ribosyl Cyclase Animals Antigens, CD* Antigens, CD38 Antigens, Differentiation / biosynthesis, chemistry, metabolism* Base Sequence Bone Marrow / metabolism Bone Marrow Cells* CHO Cells Cations, Divalent / pharmacology Cricetinae DNA Primers Humans Hydrogen-Ion Concentration Kinetics Membrane Glycoproteins / biosynthesis, chemistry, metabolism* Molecular Sequence Data N-Glycosyl Hydrolases / biosynthesis, chemistry, metabolism* NAD / metabolism Polymerase Chain Reaction Recombinant Proteins / biosynthesis, chemistry, metabolism Stromal Cells / metabolism* Transfection |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation; 0/CD157 antigen; 0/Cations, Divalent; 0/DNA Primers; 0/Membrane Glycoproteins; 0/Recombinant Proteins; 53-84-9/NAD; EC 3.2.2.-/N-Glycosyl Hydrolases; EC 3.2.2.5/ADP-ribosyl Cyclase; EC 3.2.2.5/Antigens, CD38; EC 3.2.2.5/CD38 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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