| ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism. | |
| | |
MedLine Citation:
|
PMID: 9298709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In agreement with classic studies, succinate-supplemented rat and pigeon heart and nonsynaptic brain mitochondrial free radical production is stopped by ADP additions causing the stimulation of respiration from State 4 to State 3. Nevertheless, with Complex I-linked substrates, mitochondria produce free radicals in State 3 at rates similar or somewhat higher than during resting respiration. The absence of sharp increases in free radical production during intense respiration is possible due to strong decreases of free radical leak in State 3. The results indicate that Complex I is the main mitochondrial free radical generator in State 3, adding to its already known important generation of active oxygen species in State 4. The observed rate of mitochondrial free radical production with Complex I-linked substrates in the active State 3 can help to explain two paradoxes: (a) the lack of massive muscle oxidative damage and shortening of life span due to exercise, in spite of up to 23-fold increases of oxygen consumption together with the very low levels of antioxidants present in heart, skeletal muscle, and brain; (b) the presence of some degree of oxidative stress during exercise and hyperactivity in spite of the stop of mitochondrial free radical production by ADP with succinate as substrate. |
| | |
Authors:
|
A Herrero; G Barja |
Related Documents
:
|
11881979 - Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin c again... 18337059 - Consumption of green tea favorably affects oxidative stress markers in weight-trained men. 10734519 - Megaloblastic marrow in macrocytic anaemias at kenyatta national and m p shah hospitals... 9840749 - Interaction of exercise training and chronic ethanol ingestion on testicular antioxidan... 7458309 - Effect of phenolic antioxidants on the mutagenicity of aflatoxin b1. 8829619 - Exercise training alters kinetics of antioxidant enzymes in rat tissues. 12647909 - Prevalence of obstructive airflow limitation in irish collegiate athletes. 18054809 - The 12-week progressive quadriceps resistance training improves muscle strength, exerci... 618399 - The role of the exercise test in the evaluation of patients for ischemic heart disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of bioenergetics and biomembranes Volume: 29 ISSN: 0145-479X ISO Abbreviation: J. Bioenerg. Biomembr. Publication Date: 1997 Jun |
Date Detail:
|
Created Date: 1997-11-14 Completed Date: 1997-11-14 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7701859 Medline TA: J Bioenerg Biomembr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 241-9 Citation Subset: IM |
Affiliation:
|
Department of Animal Biology-II (Animal Physiology), Faculty of Biology, Complutense University, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Diphosphate
/
metabolism* Animals Brain / metabolism*, ultrastructure Columbidae Electron Transport Complex II Free Radicals / metabolism Male Mitochondria / metabolism* Mitochondria, Heart / metabolism* Multienzyme Complexes / metabolism* Myocardium / metabolism NAD(P)H Dehydrogenase (Quinone) / metabolism* Oxidative Stress Oxidoreductases / metabolism* Oxygen Consumption Physical Exertion / physiology* Rats Rats, Wistar Succinate Dehydrogenase / metabolism* Succinic Acid / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Free Radicals; 0/Multienzyme Complexes; 110-15-6/Succinic Acid; 58-64-0/Adenosine Diphosphate; EC 1.-/Oxidoreductases; EC 1.3.5.1/Electron Transport Complex II; EC 1.3.99.1/Succinate Dehydrogenase; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lineage-specific evolution of echinoderm mitochondrial ATP synthase subunit 8.
Next Document: Antioxidant ascorbate is stabilized by NADH-coenzyme Q10 reductase in the plasma membrane.