| ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity. | |
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MedLine Citation:
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PMID: 19543786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Adiponectin, an adipose-derived hormone with central and peripheral actions, is involved in the regulation of energy homeostasis. Interactions between genetic and environmental factors have been associated with decrease in circulating adiponectin leading to obesity. AIM: We investigated whether variants of the ADIPOQ gene encoding adiponectin interact with diet to predict serum adiponectin concentration. METHODS: A cross-sectional study of healthy school-aged children of Greek origin (n = 991), aged 11.2 +/- 0.6 years was conducted in 2005-2006. DNA was genotyped for two SNPs [rs1501299 (n = 741) and rs17300539 (n = 713)] located in the ADIPOQ gene. Detailed dietary, behavioural, lifestyle, anthropometric and biochemical data were recorded for all participants. RESULTS: Both SNPs were in HWE. The rs1501299 (GG vs GT + TT) x fibre interaction was significantly associated with adiponectin concentration (P = 0.028). When fibre intake was low, GG homozygotes exhibited significantly higher adiponectin concentrations compared to T allele carriers (mean +/- SD = 5.1 +/- 2.7 vs 4.2 +/- 2.3; P = 0.020). CONCLUSIONS: In the present study, the rs1501299 x fibre interaction was significantly associated with adiponectin levels; in specific, GG homozygotes exhibited higher adiponectin levels compared to T carriers under conditions of lower fibre intake. |
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Authors:
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Ioanna Ntalla; George Dedoussis; Mary Yannakoulia; Melissa C Smart; Eirini Louizou; Sophia D Sakka; Constantina Papoutsakis; Philippa J Talmud |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-19 |
Journal Detail:
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Title: European journal of nutrition Volume: 48 ISSN: 1436-6215 ISO Abbreviation: Eur J Nutr Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 493-7 Citation Subset: IM |
Affiliation:
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Department of Dietetics, Nutrition, Harokopio University, 70 El. Venizelou St., 17671, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood*,
genetics* Alleles Analysis of Variance Child Cross-Sectional Studies Dietary Fiber / administration & dosage* Female Greece Humans Insulin Resistance / genetics Male Metabolic Syndrome X / blood, genetics Nutrigenomics Obesity / blood*, genetics Polymorphism, Single Nucleotide* |
| Grant Support | |
ID/Acronym/Agency:
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PG2005/014//British Heart Foundation; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin |
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