| ADC mapping of chronic cerebral hypoperfusion induced by carotid artery stenosis. | |
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MedLine Citation:
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PMID: 21353306 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Carotid artery stenosis is associated with the occurrence of acute and chronic ischemic lesions that increase with age in the elderly population. Diffusion Imaging and ADC mapping may be an appropriate method to investigate patients with chronic hypoperfusion consecutive to carotid stenosis. This non-invasive technique allows to investigate brain integrity and structure, in particular hypoperfusion induced by carotid stenosis diseases. The aim of this study was to evaluate the impact of a carotid stenosis on the parenchyma using ADC mapping. METHODS: Fifty-nine patients with symptomatic (33) and asymptomatic (26) carotid stenosis were recruited from our multidisciplinary consultation. Both groups demonstrated a similar degree of stenosis. All patients underwent MRI of the brain including diffusion-weighted MR imaging with ADC mapping. Regions of interest were defined in the anterior and posterior paraventricular regions both ipsilateral and contralateral to the stenosis (anterior circulation). The same analysis was performed for the thalamic and occipital regions (posterior circulation). RESULTS: ADC values of the affected vascular territory were significantly higher on the side of the stenosis in the periventricular anterior (P<0.001) and posterior (P<0.01) area. There was no difference between ipsilateral and contralateral ADC values in the thalamic and occipital regions. CONCLUSIONS: We have shown that carotid stenosis is associated with significantly higher ADC values in the anterior circulation, probably reflecting an impact of chronic hypoperfusion on the brain parenchyma in symptomatic and asymptomatic patients. This is consistent with previous data in the literature. |
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Authors:
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V Rentsch-Granges; F Assal; V Mendes Pereira; A Alimenti; P Mosimann; A de Ribaupierre; F Lazeyras; C D Becker; R Sztajzel; D Rüfenacht; K-O Lövblad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: Journal of neuroradiology. Journal de neuroradiologie Volume: - ISSN: 0150-9861 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705086 Medline TA: J Neuroradiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of neuroradiology, DISIM, Geneva University Hospital and Medical School, 4, rue Gabrielle-Perret-Gentil, 1211 Geneva 4, Switzerland; Department of radiology, Geneva University Hospital and Medical School, Geneva, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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