| ADAMTS13 deficiency, an important cause of thrombocytopenia during pregnancy. | |
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MedLine Citation:
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PMID: 19041237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present the case of a woman with congenital ADAMTS13 deficiency and discuss peripartum management of her fourth pregnancy. All four pregnancies were complicated by significant thrombocytopenia. Her first pregnancy ended with fetal demise ascribed to HELLP syndrome and placental abruption. During her second pregnancy, she was diagnosed with idiopathic thrombocytopenic purpura. Thrombotic thrombocytopenic purpura and congenital ADAMTS13 deficiency were diagnosed during the third pregnancy. She had recurrent thrombotic thrombocytopenic purpura during the fourth pregnancy and responded to treatment with fresh frozen plasma, with a successful outcome. The need for accurate diagnosis to ensure appropriate treatment is emphasized. |
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Authors:
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R Kato; A Shinohara; J Sato |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-11-28 |
Journal Detail:
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Title: International journal of obstetric anesthesia Volume: 18 ISSN: 1532-3374 ISO Abbreviation: Int J Obstet Anesth Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200430 Medline TA: Int J Obstet Anesth Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Chiba, Japan. rie.kato@nifty.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
/
deficiency*,
genetics Adult Anesthesia, Obstetrical / methods* Anesthesia, Spinal / methods* Cesarean Section / methods Female Humans Pregnancy Pregnancy Complications, Hematologic / genetics* Purpura, Thrombotic Thrombocytopenic / genetics* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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