Document Detail

ADAMTS13 deficiency, an important cause of thrombocytopenia during pregnancy.
MedLine Citation:
PMID:  19041237     Owner:  NLM     Status:  MEDLINE    
We present the case of a woman with congenital ADAMTS13 deficiency and discuss peripartum management of her fourth pregnancy. All four pregnancies were complicated by significant thrombocytopenia. Her first pregnancy ended with fetal demise ascribed to HELLP syndrome and placental abruption. During her second pregnancy, she was diagnosed with idiopathic thrombocytopenic purpura. Thrombotic thrombocytopenic purpura and congenital ADAMTS13 deficiency were diagnosed during the third pregnancy. She had recurrent thrombotic thrombocytopenic purpura during the fourth pregnancy and responded to treatment with fresh frozen plasma, with a successful outcome. The need for accurate diagnosis to ensure appropriate treatment is emphasized.
R Kato; A Shinohara; J Sato
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-11-28
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  18     ISSN:  1532-3374     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Department of Anesthesiology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Chiba, Japan.
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MeSH Terms
ADAM Proteins / deficiency*,  genetics
Anesthesia, Obstetrical / methods*
Anesthesia, Spinal / methods*
Cesarean Section / methods
Pregnancy Complications, Hematologic / genetics*
Purpura, Thrombotic Thrombocytopenic / genetics*
Treatment Outcome
Reg. No./Substance:
EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human

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