| ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections. | |
| | |
MedLine Citation:
|
PMID: 23245439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) is a recently identified family of extracellular metalloproteinases that has been shown to participate in tissue destruction. We hypothesized that ADAMTS-1 and ADAMTS-4 expression is increased in aortic tissues from patients with thoracic aortic aneurysms and dissections. METHODS: We examined ADAMTS-1 and ADAMTS-4 expression in human descending thoracic aortic aneurysms (n = 14), chronic descending thoracic aortic dissections (n = 16), and descending thoracic aortas from age-matched control organ donors (n = 12). In these tissues, we also evaluated the degradation of versican, a proteoglycan substrate of ADAMTS-1 and ADAMTS-4. In cultured macrophages, we examined whether ADAMTS-4 functions in macrophage infiltration by using a transwell assay. RESULTS: ADAMTS-1 and ADAMTS-4 protein and mRNA expression was significantly higher in thoracic aortic aneurysm and dissection tissues than in control aortic tissues. Double immunofluorescence staining showed the expression of ADAMTS-1 and ADAMTS-4 in smooth muscle cells and macrophages. Consistent with the upregulation of ADAMTS-1 and ADAMTS-4 in thoracic aortic aneurysm and dissection tissues, versican was degraded significantly more in these tissues than in control aortic tissues. In cultured macrophages, transforming growth factor-β increased ADAMTS-4 protein levels and induced macrophage invasion, and the knockdown of ADAMTS-4 reduced cell invasion. CONCLUSIONS: Increased expression of ADAMTS proteins may promote thoracic aortic aneurysm progression by degrading versican and facilitating macrophage invasion. |
| | |
Authors:
|
Pingping Ren; Lin Zhang; Gaiping Xu; Laura C Palmero; Paul T Albini; Joseph S Coselli; Ying H Shen; Scott A LeMaire |
Related Documents
:
|
3948979 - Ultrastructural study of canine aortic damage caused by disturbance of transmural trans... 22985459 - Hemitruncus arteriosus: cardiac magnetic resonance angiography findings. 2783099 - Report of four cases of aneurysm complicating patch aortoplasty for repair of coarctati... 7272859 - Ascending aorta to bifemoral artery bypass. 12072989 - A technique for thoracoscopic aortopericardiosternopexy. 21828409 - Pharmacomechanic approach for restoration of flow in occluded ectatic right coronary ar... 9467519 - Can duplex ultrasonography select appropriate patients for carotid endarterectomy? 22245769 - Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in e... 21807299 - Transfemoral aortic valve replacement with the sapien xt valve: step-by-step. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-12-13 |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 95 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-22 Completed Date: 2013-03-26 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 570-7 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ADAM Proteins
/
blood* Aneurysm, Dissecting / blood* Aortic Aneurysm, Thoracic / blood* Female Humans Male Middle Aged Procollagen N-Endopeptidase / blood* |
| Grant Support | |
ID/Acronym/Agency:
|
5R01HL085341/HL/NHLBI NIH HHS; P50 HL083794/HL/NHLBI NIH HHS; R01 HL085341/HL/NHLBI NIH HHS; UL1 RR024148/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS1 protein, human; EC 3.4.24.-/aggrecanase-1; EC 3.4.24.14/Procollagen N-Endopeptidase |
| Comments/Corrections | |
Comment In:
|
Ann Thorac Surg. 2013 Feb;95(2):577-8
[PMID:
23336870
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of Radiology Business Models.
Next Document: The effect of surgical and transcatheter aortic valve replacement on mitral annular anatomy.