| ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome. | |
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MedLine Citation:
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PMID: 20509157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the use of maternal serum ADAM12 as a second-trimester Down syndrome serum marker. METHODS: Samples from a total of 46 Down syndrome pregnancies and 184 unaffected singleton pregnancies matched for gestational age and maternal weight were retrieved from storage and measured for ADAM12; 35 false-positive pregnancies were included among the controls to assess reductions in false-positive rates by inclusion of ADAM12 in the risk calculation of an algorithm that used alpha-fetoprotein (AFP) and human chorionic gonadotrophin (hCG) (double screen). RESULTS: ADAM12 was measured and expressed as multiple of the gestation-specific median (MoM) and corrected for maternal weight. The median ADAM12 level in the affected pregnancies was 1.26 MoM compared with 1.0 MoM in the unaffected control pregnancies (p < 0.05). In unaffected pregnancies, there was a significant correlation between ADAM12 and AFP (r = 0.314) but not hCG (r = 0.018). Statistical modeling predicted that ADAM12 as a second serum marker could increase the detection rate from 48 to 85%, while reducing the false-negative and false-positive rates. CONCLUSION: ADAM12 can be used as an effective second-trimester serum marker for prenatal screening of Down syndrome. |
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Authors:
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Min Wang; Shiming Lu; Yuning Zhu; Hui Li |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 561-4 Citation Subset: IM |
Affiliation:
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Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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analysis,
blood* Adult Case-Control Studies Down Syndrome / blood, diagnosis* Efficiency False Positive Reactions Female Gestational Age Humans Mass Screening / methods, standards Membrane Proteins / analysis, blood* Pregnancy Pregnancy Trimester, Second / blood* Prenatal Diagnosis / methods*, standards Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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