Document Detail

ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome.
MedLine Citation:
PMID:  20509157     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the use of maternal serum ADAM12 as a second-trimester Down syndrome serum marker. METHODS: Samples from a total of 46 Down syndrome pregnancies and 184 unaffected singleton pregnancies matched for gestational age and maternal weight were retrieved from storage and measured for ADAM12; 35 false-positive pregnancies were included among the controls to assess reductions in false-positive rates by inclusion of ADAM12 in the risk calculation of an algorithm that used alpha-fetoprotein (AFP) and human chorionic gonadotrophin (hCG) (double screen). RESULTS: ADAM12 was measured and expressed as multiple of the gestation-specific median (MoM) and corrected for maternal weight. The median ADAM12 level in the affected pregnancies was 1.26 MoM compared with 1.0 MoM in the unaffected control pregnancies (p < 0.05). In unaffected pregnancies, there was a significant correlation between ADAM12 and AFP (r = 0.314) but not hCG (r = 0.018). Statistical modeling predicted that ADAM12 as a second serum marker could increase the detection rate from 48 to 85%, while reducing the false-negative and false-positive rates. CONCLUSION: ADAM12 can be used as an effective second-trimester serum marker for prenatal screening of Down syndrome.
Min Wang; Shiming Lu; Yuning Zhu; Hui Li
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  IM    
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
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MeSH Terms
ADAM Proteins / analysis,  blood*
Case-Control Studies
Down Syndrome / blood,  diagnosis*
False Positive Reactions
Gestational Age
Mass Screening / methods,  standards
Membrane Proteins / analysis,  blood*
Pregnancy Trimester, Second / blood*
Prenatal Diagnosis / methods*,  standards
Young Adult
Reg. No./Substance:
0/Membrane Proteins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins

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