Document Detail

ADA genetic polymorphism and the effect of smoking on neonatal bilirubinemia and developmental parameters.
MedLine Citation:
PMID:  18562134     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Genetic variability of metabolic enzymes may influence the effect of cigarette smoking on intrauterine development and on early neonatal events. AIMS: To investigate the role of adenosine deaminase genetic polymorphism on the effect of smoking on neonatal bilirubinemia and developmental parameters. STUDY DESIGN: Analysis of association between adenosine deaminase phenotypes and neonatal developmental parameters. Prospective study of serum bilirubin level in relation to adenosine deaminase phenotype. METHODS: We have studied 360 consecutive newborn infants from the Caucasian population of Rome. Serum bilirubin concentration was determined at birth and every 24 h for the first five days. RESULTS: Overall maternal smoking is associated with a slight decrease in the incidence of phototherapy (13.4% in non smoking vs 11.7% in smoking mothers) and with a reduction of birth weight (3374 g in non smoking mothers vs 3133 g in smoking mothers). There is a significant interaction between smoke and adenosine deaminase. While in non smoking mothers the incidence of phototherapy in carriers of ADA 2 allele is higher than in ADA 1 phenotype, in infants from smoking mothers the pattern is reversed and the incidence of phototherapy in carriers of ADA 2 allele is lower than in infants with ADA 1 phenotype. Other neonatal bilirubin parameters follow a similar pattern of interaction between smoking and ADA. The negative effect of smoke on birth weight is much more evident in infant with ADA 1 phenotype than in those carrying the ADA 2 allele. CONCLUSIONS: The data suggest that ADA phenotype modifies the effect of smoking on developmental and bilirubin parameters.
F Gloria-Bottini; A Magrini; E Cozzoli; A Bergamaschi; E Bottini
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Publication Detail:
Type:  Journal Article     Date:  2008-06-17
Journal Detail:
Title:  Early human development     Volume:  84     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  739-43     Citation Subset:  IM    
Division of Biopathology of Human Populations and Environmental Pathology, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
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MeSH Terms
Adenosine Deaminase / genetics*,  metabolism
Bilirubin / blood*
Birth Weight
Electrophoresis, Starch Gel
Genetic Variation
Gestational Age
Hyperbilirubinemia, Neonatal / blood,  enzymology,  genetics
Infant, Newborn / blood*
Polymorphism, Genetic
Prospective Studies
Smoking / adverse effects*
Reg. No./Substance:
0/Isoenzymes; 635-65-4/Bilirubin; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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