| An AD-Related Neuroprotector Rescues Transformed Rat Retinal Ganglion Cells from CoCl(2)-Induced Apoptosis. | |
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MedLine Citation:
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PMID: 22222604 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Some ocular diseases characterized by apoptotic death of retinal ganglion cells (RGCs) and Alzheimer's disease (AD) are chronic neurodegenerative disorders and have similarities in neuropathology. Humanin (HN) is known for its ability to suppress neuronal death induced by AD-related insults. In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells. Hypoxia mimetic compound cobalt chloride (CoCl(2) ) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects. This finding may provide new therapeutics for the retinal neurodegenerative diseases targeting neuroprotection. |
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Authors:
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Jie Men; Xiaohui Zhang; Yang Yang; Dianwen Gao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-5 |
Journal Detail:
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Title: Journal of molecular neuroscience : MN Volume: - ISSN: 1559-1166 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002991 Medline TA: J Mol Neurosci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Shengjing Hospital, China Medical University, Sanhao street 36, Heping district, Shenyang, 110004, Liaoning Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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