Document Detail

ACTH suppression after oral administration of cortisone in Addisonian and adrenalectomized patients.
MedLine Citation:
PMID:  6289586     Owner:  NLM     Status:  MEDLINE    
Plasma cortisol and the corresponding ACTH concentrations were determined before, and for 6 h following a single oral dose of 25 mg cortisone acetate in 7 patients with Addison's disease, 6 patients adrenalectomized for Cushing's disease and 1 patient adrenalectomized for congenital adrenal hyperplasia. The basal plasma cortisol concentrations 12 h after an evening dose of cortisone acetate 12.5 mg were below 100 nmol/l, and the corresponding ACTH concentrations were markedly elevated in all patients. Great interindividual variations were found in cortisol peak concentrations (Cmax) and the time to peak values, but without significant differences between the two patient groups. The maximal ACTH suppression occurred within 60-330 min after the cortisol Cmax, and was not significantly different in the two groups. The suppressed plasma ACTH concentrations were considerably above normal in 3 of the patients with Addison's disease and in 4 of the 6 patients adrenalectomized for Cushing's disease, including 2 patients with Nelson's syndrome. A similar degree of impaired ACTH suppression in patients with Addison's disease as in adrenalectomized patients suggests the occurrence of a secondary hypothalamic-pituitary dysfunction with ACTH hypersecretion in Addison's disease. The adequacy of the commonly used adrenocortical replacement therapy and its possible relation to the impaired ACTH suppression is discussed.
S Aanderud; O L Myking; H H Bassøe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  100     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  588-94     Citation Subset:  IM    
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MeSH Terms
Addison Disease / blood,  drug therapy*,  physiopathology
Administration, Oral
Adrenocorticotropic Hormone / blood*
Cortisone / analogs & derivatives*,  therapeutic use
Hydrocortisone / blood*
Hypothalamo-Hypophyseal System / physiopathology
Middle Aged
Reg. No./Substance:
50-04-4/cortisone acetate; 50-23-7/Hydrocortisone; 53-06-5/Cortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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