| ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies. | |
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MedLine Citation:
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PMID: 2832292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ketoconazole has been used as a palliative treatment of Cushing's syndrome, due to its ability to lower cortisol production. We evaluated the effects of ovine Corticotropin Releasing Hormone (oCRH) 100 micrograms i.v. on ACTH and cortisol levels in 6 patients with Cushing's disease before and after treatment with ketoconazole 600 mg/day. Both hormones increased after oCRH. During ketoconazole, cortisol was lowered to normal levels and its response to oCRH was impaired. After treatment, basal ACTH showed variable changes while the response to oCRH was markedly enhanced compared to that before ketoconazole. In vitro: In a continuous perfusion system of isolated anterior pituitary cells from rats or human anterior pituitary adenoma, producing ACTH, ketoconazole 10(-5)-10(-6) M showed no inhibitory effects on both basal or lisine-vasopressin and oCRH stimulated ACTH secretion. Our findings confirm the inhibitory action of ketoconazole on basal and stimulated cortisol secretion. No inhibition of ACTH levels was observed both in vivo and in vitro. |
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Authors:
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M Boscaro; N Sonino; A Rampazzo; A M Menegus; F Mantero |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research. Supplement series Volume: 16 ISSN: 0170-5903 ISO Abbreviation: Horm. Metab. Res. Suppl. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-10 Completed Date: 1988-05-10 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0330417 Medline TA: Horm Metab Res Suppl Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 60-2 Citation Subset: IM |
Affiliation:
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Institute of Semeiotica Medica, University of Padua, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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secretion Adrenocorticotropic Hormone / secretion* Adult Animals Corticotropin-Releasing Hormone / diagnostic use* Cushing Syndrome / drug therapy, physiopathology* Female Humans Hydrocortisone / secretion Ketoconazole / pharmacology*, therapeutic use Kinetics Male Middle Aged Pituitary Gland, Anterior / drug effects, secretion Pituitary Neoplasms / secretion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 65277-42-1/Ketoconazole; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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