Document Detail

ACTH and prolactin deficiency.
MedLine Citation:
PMID:  3008475     Owner:  NLM     Status:  MEDLINE    
A 35 year old woman suffering from ACTH and prolactin (Prl) deficiency is described. Her symptoms of adrenal insufficiency appeared gradually after her first pregnancy in 1970; however, she conceived twice more and delivered healthy babies in 1972 and 1974, which she could not breast feed due to lack of milk. During an episode of pneumonia in 1977 she suffered acute adrenal insufficiency, after which she began treatment with hydrocortisone. Her pituitary reserve for TSH, GH, LH and FSH was normal, but her ACTH and Prl levels were undectable and did not respond to acute iv challenges of corticotrophin-releasing factor (CRF) and TRH, respectively. Autoantibodies, including antilactotroph titres, were negative, except for a positive pituitary immunofluorescence to ACTH. There was also no ACTH stimulation to a prolonged infusion of CRF followed by an acute iv bolus. These results, together with the gradual onset of symptoms which worsened after each pregnancy, suggest a possible autoimmune aetiology of her pituitary ACTH and Prl deficiencies.
M L Puig; S M Webb; C del Pozo; J R Espinosa; M J Martínez; A de Leiva
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  111     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / deficiency*
Autoantibodies / analysis
Corticotropin-Releasing Hormone / pharmacology
Follicle Stimulating Hormone / blood
Growth Hormone / blood
Hypothalamo-Hypophyseal System / physiopathology*
Luteinizing Hormone / blood
Pituitary-Adrenal System / physiopathology*
Prolactin / deficiency*
Thyrotropin / blood
Thyrotropin-Releasing Hormone / pharmacology
Reg. No./Substance:
0/Autoantibodies; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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