Document Detail

ACP1 and human adaptability. 2. Association with season of conception.
MedLine Citation:
PMID:  9402961     Owner:  NLM     Status:  MEDLINE    
We have studied the pattern of association between the season of conception and cytosolic low molecular weight phosphotyrosine phosphatase (ACP1) genetic polymorphism in 329 consecutively newborn infants from the population of Penne and 361 consecutively newborn infants from the population of Rome. In addition, 329 mothers were studied in the population of Penne. A concordant, highly significant association was observed in the two populations between ACP1 parameters and the season of conception of newborn infants. The total activity of ACP1 shows a minimum in infants conceived in January-February and a maximum in those conceived at the end of the solar year. Analysis of the joint mother-newborn ACP1 distribution in relation to the season of fertilisation has shown that among mothers carrying ACP1*A (the allele showing the lowest activity), the proportion of newborns carrying this allele is higher in those conceived in the first months of the year than in those conceived subsequently. Since ACP1 probably functions as a phosphotyrosine phosphatase and as a flavin mononucleotide phosphatase, low activity could enhance the metabolic rate and would be advantageous in a cold environment. The cycle of variation of ACP1 in infants follows the cycle of solar illumination. It is possible that individuals who have a genetic background allowing them to adapt easily and readily to seasonal demand are more successful in reproducing themselves. The population of zygotes conceived in a given season would therefore reproduce the pattern of gene combination more fit for that season.
F Gloria-Bottini; N Lucarini; R Palmarino; M La Torre; A Amante; E Bottini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  101     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Università di Roma Tor Vergata, Dipartimento di Chirurgia, Italy.
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MeSH Terms
Acclimatization / genetics*
Infant, Newborn
Isoenzymes / genetics*
Polymorphism, Genetic
Protein Tyrosine Phosphatases / genetics*
Proto-Oncogene Proteins*
Reg. No./Substance:
0/Isoenzymes; 0/Proto-Oncogene Proteins; EC protein, human; EC Tyrosine Phosphatases

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