| ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy. | |
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MedLine Citation:
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PMID: 18055749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prenatal diagnosis of fetal chromosomal abnormalities is the most common indication for invasive prenatal testing. The prevalence of chromosomal abnormalities in clinically recognized early pregnancy loss is greater than 50%(1). Fetuses with aneuploidy account for 6-11% of all still births and neonatal deaths(2). Chromosomal abnormalities that are compatible with life but cause considerable morbidity occur in 0.65% of newborns, and structural chromosomal rearrangements that will eventually affect reproduction occur in 0.2% of newborns(3). Consequently, screening and diagnostic programs to detect the most common autosomal trisomies in liveborn infants, including Down syndrome, are well established. The purpose of this document is to provide clinical management guidelines for the prenatal diagnosis of these aneuploidies. |
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Authors:
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Publication Detail:
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Type: Journal Article; Practice Guideline |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 110 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-01-17 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1459-67 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amniocentesis / standards* Aneuploidy* Chorionic Villi Sampling / standards* Chromosome Disorders / diagnosis* Evidence-Based Medicine Female Humans Middle Aged Pregnancy Prenatal Diagnosis / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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