| ACE inhibitors and protection against kidney disease progression in patients with type 2 diabetes: what's the evidence. | |
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MedLine Citation:
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PMID: 12461306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although angiotensin-converting enzyme inhibitors are frequently used as antihypertensive agents to lower blood pressure and slow progression of nephropathy in patients with type 2 diabetes, evidence of their efficacy has been drawn primarily from small trials with surrogate end points. No adequately powered, long-term trials have tested their effects to reduce the incidence of hard end points, such as progression to end-stage renal disease or even doubling of serum creatinine in the population of patients with nephropathy from type 2 diabetes. While the results of angiotensin-converting enzyme inhibitor trials from nondiabetic causes and even type 1 diabetes may be extrapolated to the patient with nephropathy associated with type 2 diabetes, the hard evidence is not available. This review critically evaluates the limited evidence in support of angiotensin-converting enzyme inhibitors as renal-protective agents in people with type 2 diabetes. |
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Authors:
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George L Bakris; Matthew Weir |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 4 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-12-03 Completed Date: 2003-04-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 420-3 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Le Jacq Communications, Inc. |
Affiliation:
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Department of Preventive Medicine, Rush-Presbyterian-St. Lukes Medical Center, Chicago, IL 60612, USA. gbakris@rush.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Clinical Trials as Topic Diabetes Mellitus, Type 2 / drug therapy*, enzymology, physiopathology Diabetic Nephropathies / drug therapy*, enzymology Disease Progression Humans Kidney Failure, Chronic / drug therapy*, enzymology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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