Document Detail


ACE-inhibitor treatment attenuates atrial structural remodeling in patients with lone chronic atrial fibrillation.
MedLine Citation:
PMID:  16382287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic atrial fibrillation (AF) is characterized by a remodeling process which involves the development of fibrosis. Since angiotensin II has been suspected to be involved in this process, the aim of our study was to investigate a possible influence of an ACE-I therapy in patients with chronic AF regarding the occurrence of left atrial structural remodeling. METHODS: Atrial tissue samples were obtained from patients with lone chronic AF or sinus rhythm (SR). Collagen I, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) protein expression were measured by quantitative Western Blotting techniques and calculated as mean +/- SEM. Histological tissue samples were used for calculating microvessel density (microvessel/mm(2) +/- SEM). RESULTS: In AF, the collagen amount was higher (1.78 +/- 0.21; p = 0.01) vs. SR (0.37 +/- 0.07) accompanied by declining microcapillary density (AF: 145 +/- 13 vs. SR: 202 +/- 9; p = 0.01). Additionally, a negative correlation (p = 0.01) between collagen content and microcapillary density was observed. To investigate the influence of an ACE-I therapy on this remodeling process, patient groups were divided into AF and SR both with or without ACE-I. Interestingly, there was a significantly lower expression of collagen I in AF with ACE-I (1.04 +/- 0.26) vs. AF without ACE-I treatment (2.07 +/- 0.24, p = 0.02). The microcapillaries were not diminished in AF with ACE-I (180 +/- 15) vs. SR with ACE-I (196 +/- 9), but there was a significant rarification in AF without ACE-I (123 +/- 18; p = 0.03). The expression of VEGF and bFGF did not reveal any significant differences. CONCLUSION: In patients undergoing ACE-I treatment: atrial structural remodeling was attenuated and the loss of atrial microcapillaries was prevented.
Authors:
A Boldt; A Scholl; J Garbade; M E Resetar; F W Mohr; J F Gummert; St Dhein
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Publication Detail:
Type:  Journal Article     Date:  2005-12-29
Journal Detail:
Title:  Basic research in cardiology     Volume:  101     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-12-01     Revised Date:  2007-05-02    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Affiliation:
University of Leipzig-Heart Center, Department of Cardiac Surgery, Strümpellstrasse 19, 04289 Leipzig, Germany. andreasboldt@web.de
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology*,  therapeutic use
Atrial Fibrillation / drug therapy*,  metabolism,  pathology
Blotting, Western
Capillaries / drug effects
Chronic Disease
Collagen / metabolism
Coronary Vessels / drug effects
Densitometry
Fibroblast Growth Factor 2 / analysis
Fibrosis
Heart Atria / drug effects*,  pathology
Humans
Middle Aged
Vascular Endothelial Growth Factor A / analysis
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 103107-01-3/Fibroblast Growth Factor 2; 9007-34-5/Collagen

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