Document Detail

ACE inhibition with perindopril and atherogenesis-induced structural and functional changes in minipig arteries.
MedLine Citation:
PMID:  8343488     Owner:  NLM     Status:  MEDLINE    
The effects of angiotensin-converting-enzyme (ACE) inhibition on atherosclerosis-induced changes in arterial function are unknown, as well as whether they are coupled to improvements of structural alterations in the arterial wall. An atherogenic (A) diet and the ACE inhibitor perindopril (P) were given concomitantly for 4 months to seven adult Pitman-Moore minipigs (7 months of age; A+P animals), which were compared with seven A and seven control (C) animals. Perindopril, at a daily dose of 4 mg PO that is commonly used in the clinical setting, induced a continuous 70% inhibition of serum ACE activity. At the end of the study, the atherosclerosis-induced impairment of arterial flow was investigated via the hemodynamics and vascular rheology of hindlimb arteries in non-barbiturate-anesthetized pigs. Structural alterations were evaluated from the histopathology of lesions in the arterial tree (abdominal aorta, left interventricular coronary artery [LIVCA], and brachiocephalic trunk [BCT]), with particular attention given to the analysis of the structure and composition of aortic elastic fibers. Atherosclerosis impaired the function of both capacitance and resistance arteries. Blood pressure (BP) rose significantly because of increased hindlimb peripheral resistance (HPR) and aortic input impedance (Zc), although blood flow was not affected. Altered aortic stress and elastic responses revealed that the stiffness of the aorta was markedly increased because of increased wall tension and reduced viscoelasticity, the viscous component being blunted in the arterial wall. Perindopril significantly opposed these alterations by reducing BP, HPR, and Zc and by returning parietal stiffness values to C values by increasing aortic compliance. ACE inhibition prevented the alteration of both stress and elastic responses. Major fibroproliferative fatty lesions were observed in the aorta and LIVCA, while moderate fibrosclerotic lesions were found in the BCT. Computerized densitometric analysis of orcein-stained elastin showed that elastic laminae fragmentation was prominent in the abdominal aorta, less in the LIVCA, and moderate in the BCT. Furthermore, the elastin content was reduced in the atherosclerotic aorta, although this loss of elastin was not associated with changes in the biochemical nature of alkali-insoluble elastin. Perindopril significantly prevented the development of atherosclerosis in the abdominal aorta, LIVCA, and BCT by decreasing the cross-sectional area of lesions as well as the number of lipid-laden cells in the abdominal aorta and LIVCA. In the abdominal aorta, ACE inhibition significantly prevented the alteration of elastic laminae by specifically preventing elastolytic fragmentation of dense elastic laminae, but it didn ot modify elastin content.(ABSTRACT TRUNCATED AT 400 WORDS)
P Charpiot; P H Rolland; A Friggi; P Piquet; E Scalbert; H Bodard; A Barlatier; V Latrille; P Tranier; C Mercier
Related Documents :
19935078 - Effects of endogenous no and of deta nonoate in arteriogenesis.
6885038 - The morphology of ascending aortic aneurysms.
2767258 - Is extracorporeal shock wave lithotripsy safe in patients with calcific arterial disease?
7714878 - Scanning electron microscopy of microarterial anastomoses with a diode laser: compariso...
8759208 - Scalp necrosis in temporal (giant cell) arteritis:implications for the dermatologic sur...
21459548 - Multiple tuberculous aneurysms of the aorta.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association     Volume:  13     ISSN:  1049-8834     ISO Abbreviation:  Arterioscler. Thromb.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-03     Completed Date:  1993-09-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9101388     Medline TA:  Arterioscler Thromb     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1125-38     Citation Subset:  IM    
INSERM, Laboratoire de Chimie Biologique, Faculté de Pharmacie, Marseille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Arteries / pathology*,  physiopathology*
Arteriosclerosis / blood,  pathology*,  physiopathology*
Diet, Atherogenic
Indoles / pharmacology*
Reference Values
Swine, Miniature
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 82834-16-0/Perindopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Does autoimmunity to S-antigen play a role in Fuchs' heterochromic cyclitis?
Next Document:  Plasma lipid, lipoprotein cholesterol, and apoprotein distributions in selected US communities. The ...