Document Detail


Is ACE gene polymorphism a useful marker for diabetic albuminuria in Japanese NIDDM patients?
MedLine Citation:
PMID:  8941475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We studied the relationship between an insertion/deletion (I/D) polymorphism in the ACE gene and albuminuria/proteinuria in Japanese NIDDM patients. RESEARCH DESIGN AND METHODS: A total of 142 Japanese NIDDM patients (89 men, 53 women) with a known diabetes duration of 14 +/- 5 (mean +/- SD) years and an age of 56 +/- 6 years were divided into three groups according to the stage of nephropathy: 41 patients with normoalbuminuria, 47 patients with microalbuminuria, and 54 with overt proteinuria. The three groups were similar in age, diabetes duration, and recent HbAic level. RESULTS: The distribution of DD, ID, and II genotypes of the ACE gene did not differ among the three groups (10, 46, and 44% in the normoalbuminuric patients; 13, 53, and 34% in the microalbuminuric patients; and 15, 46, and 39% in the proteinuric patients, respectively). Meanwhile, the frequency of the D allele in the proteinuric male patients was slightly higher than in the normoalbuminuric male patients (45 vs. 27%, chi 2 = 3.9, P < 0.05), while the D allele frequency was nonsignificantly lower in the proteinuric female patients than in the normoalbuminuric female patients. CONCLUSION: These results did not support the hypothesis that the genotype of the ACE gene would be a clinically useful genetic marker for predicting the development of nephropathy in Japanese NIDDM patients. However, the role of D allele of ACE gene in the progression of nephropathy in male patients remains to be seen.
Authors:
S Nakajima; T Baba; Y Yajima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes care     Volume:  19     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1420-2     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Kitasato University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Albuminuria*
Creatinine / blood
DNA Transposable Elements
Diabetes Mellitus, Type 2 / genetics*,  physiopathology*,  urine
Female
Genetic Markers*
Genotype
Hemoglobin A, Glycosylated / analysis
Humans
Japan
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Sequence Deletion
Sex Characteristics
Chemical
Reg. No./Substance:
0/DNA Transposable Elements; 0/Genetic Markers; 0/Hemoglobin A, Glycosylated; 60-27-5/Creatinine; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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