| Is ACE gene polymorphism a useful marker for diabetic albuminuria in Japanese NIDDM patients? | |
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MedLine Citation:
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PMID: 8941475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We studied the relationship between an insertion/deletion (I/D) polymorphism in the ACE gene and albuminuria/proteinuria in Japanese NIDDM patients. RESEARCH DESIGN AND METHODS: A total of 142 Japanese NIDDM patients (89 men, 53 women) with a known diabetes duration of 14 +/- 5 (mean +/- SD) years and an age of 56 +/- 6 years were divided into three groups according to the stage of nephropathy: 41 patients with normoalbuminuria, 47 patients with microalbuminuria, and 54 with overt proteinuria. The three groups were similar in age, diabetes duration, and recent HbAic level. RESULTS: The distribution of DD, ID, and II genotypes of the ACE gene did not differ among the three groups (10, 46, and 44% in the normoalbuminuric patients; 13, 53, and 34% in the microalbuminuric patients; and 15, 46, and 39% in the proteinuric patients, respectively). Meanwhile, the frequency of the D allele in the proteinuric male patients was slightly higher than in the normoalbuminuric male patients (45 vs. 27%, chi 2 = 3.9, P < 0.05), while the D allele frequency was nonsignificantly lower in the proteinuric female patients than in the normoalbuminuric female patients. CONCLUSION: These results did not support the hypothesis that the genotype of the ACE gene would be a clinically useful genetic marker for predicting the development of nephropathy in Japanese NIDDM patients. However, the role of D allele of ACE gene in the progression of nephropathy in male patients remains to be seen. |
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Authors:
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S Nakajima; T Baba; Y Yajima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes care Volume: 19 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-07 Completed Date: 1997-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1420-2 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kitasato University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria* Creatinine / blood DNA Transposable Elements Diabetes Mellitus, Type 2 / genetics*, physiopathology*, urine Female Genetic Markers* Genotype Hemoglobin A, Glycosylated / analysis Humans Japan Male Middle Aged Peptidyl-Dipeptidase A / genetics* Polymorphism, Genetic* Sequence Deletion Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/DNA Transposable Elements; 0/Genetic Markers; 0/Hemoglobin A, Glycosylated; 60-27-5/Creatinine; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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