Document Detail

ACE gene polymorphism in Turkish children with nephrotic syndrome.
MedLine Citation:
PMID:  16825089     Owner:  NLM     Status:  MEDLINE    
Since 1990, the role of angiotensin converting enzyme (ACE) gene polymorphism in various renal and cardiac diseases is still debated. This study comprised 71 pediatric patients with nephrotic syndrome, 47 males (66%) and 24 females (34%) with a mean age of 57.4 +/- 37.6 months, and a control group of 83 healthy males (59%) and 57 healthy females (41%) with a mean age of 505 +/- 160.5 months. The distribution of the ACE genotype in the control group was II, 11%; ID, 53%; and DD, 36%, and the nephrotic syndrome was II, 4%; ID, 78%; and DD, 18%. Angiotensin-converting enzyme genotypes were significantly different between patients and control groups (p<0.05). The study groups consisted of 52 (73%) with steroid-sensitive nephrotic syndrome (SNSS) and 19 (27%) with steroid-resistant nephrotic syndrome (SRNS). The distribution of the ACE genotype was II, 6%; ID, 75%; and DD, 19% in the SSNS population and ID, 84% and DD, 16% in the SRNS population. No statistically significant difference was found between steroid sensitivity and ACE genotypes (p=0.5). The results show that ACE I/D polymorphism does not contribute to the steroid resistance, even though this study indicates that the presence of the I/D genotype has a much higher risk--approximately 2.8 times--of having nephrotic syndrome. Further studies with a larger number of patients are needed.
Umit Sizmaz Celik; Aytül Noyan; Aysun K Bayazit; Mithat Büyükçelik; Hasan Dursun; Ali Anarat; Gülen Attila; Selçuk Matyar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Renal failure     Volume:  28     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-08-29     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  IM    
Department of Pediatric Nephrology, Cukurova University, School of Medicine, Adana, Turkey.
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MeSH Terms
Child, Preschool
Drug Resistance
Nephrotic Syndrome / drug therapy,  genetics*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Steroids / therapeutic use
Reg. No./Substance:
0/Steroids; EC A

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