Document Detail


ACE and MTHFR gene polymorphisms in unexplained recurrent pregnancy loss.
MedLine Citation:
PMID:  18588608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To assess the association between polymorphisms in angiotensin converting enzyme and methylene tetrahydrofolate reductase genes and recurrent pregnancy loss by a case-control study in South Indian women. METHODS: DNA was extracted from peripheral blood leukocytes of 104 women with Recurrent Pregnancy Loss (RPL) and 120 controls. Genotyping of ACE Insertion Deletion and MTHFR C677T polymorphism were carried out by PCR and PCR-RFLP, respectively. RESULTS: No statistically significant difference was observed in the distribution of genotypes between cases and controls for ACE and MTHFR polymorphisms. Further, the combination of MTHFR and ACE genotypes failed to reveal an association. CONCLUSION: In conclusion, the present study reveals lack of association of MTHFR C677T and ACE I/D polymorphisms in RPL in South Indian women. However, we cannot exclude the possibility that other polymorphisms of ACE and MTHFR genes could be associated with the disease and might be clinically useful as a marker to assess risk for RPL.
Authors:
Venkatesan Vettriselvi; Krishnaswami Vijayalakshmi; Solomon F D Paul; Perumal Venkatachalam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
Department of Human Genetics, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*
Adult
Case-Control Studies
DNA / blood
Female
Genotype
Humans
India
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic / genetics*
Pregnancy
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 3.4.15.1/Peptidyl-Dipeptidase A

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