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ACCELERATED CELL DEATH2 suppresses mitochondrial oxidative bursts and modulates cell death in Arabidopsis.
MedLine Citation:
PMID:  21988537     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Arabidopsis ACCELERATED CELL DEATH 2 (ACD2) protein protects cells from programmed cell death (PCD) caused by endogenous porphyrin-related molecules like red chlorophyll catabolite or exogenous protoporphyrin IX. We previously found that during bacterial infection, ACD2, a chlorophyll breakdown enzyme, localizes to both chloroplasts and mitochondria in leaves. Additionally, acd2 cells show mitochondrial dysfunctions. In plants with acd2 and ACD2(+) sectors, ACD2 functions cell autonomously, implicating a pro-death ACD2 substrate as cell non-autonomous in promoting spreading PCD. ACD2 targeted solely to mitochondria can reduce the accumulation of an ACD2 substrate that originates in chloroplasts, indicating that ACD2 substrate molecules are likely mobile within cells. Two different light-dependent reactive oxygen bursts in mitochondria play prominent and causal roles in the acd2 PCD phenotype. Finally, ACD2 can complement acd2 when targeted to mitochondria or chloroplasts, respectively, as long as it is catalytically active; the ability to bind substrate is not sufficient for ACD2 to function in vitro or in vivo. Together the data suggest that ACD2 localizes dynamically during infection to protect cells from pro-death mobile substrate molecules, some of which may originate in chloroplasts, but have major effects on mitochondria.
Authors:
Gopal K Pattanayak; Sujatha Venkataramani; Stefan Hortensteiner; Lukas Kunz; Bastien Christ; Michael Moulin; Alison G Smith; Yukihiro Okamoto; Hitoshi Tamiaki; Masakazu Sugishima; Jean T Greenberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-11
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  -     ISSN:  1365-313X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd and the Society for Experimental Biology.
Affiliation:
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637 Institute of Plant Biology, University of Zurich, CH-8008 Zurich, Switzerland Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB23EA, United Kingdom Department of Bioscience and Biotechnology, Faculty of Science and Engineering, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan Department of Medical Biochemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
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