| ABO blood groups and thrombosis: a causal association, but is there value in screening? | |
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MedLine Citation:
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PMID: 21453026 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABO(H) antigens are expressed on red cells and on von Willebrand factor. An association between groups other than O and thrombosis exists: an effect that is predominantly mediated by von Willebrand factor. Overall, the risk of venous thrombosis associated with non-O has been estimated at 1.75-fold, with a higher risk (∼2.4-fold) in those with the least O(H) antigen (a combined group of A(1)A(1)/A(1)B/BB). Preliminary evidence also suggests that blood group may influence the venous thromboembolism risk associated with factor V Leiden. Overall, ABO(H) has a more modest effect on arterial disease, with a consistent effect observed in peripheral vascular disease and no influence evident with angina. A modest effect on myocardial infarction and stroke has been reported in some but not all studies. The potential mechanisms whereby blood group influences thrombosis, the limitations of current evidence and the current and future role of blood groups in identifying those at risk of arterial and venous disease is discussed. |
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Authors:
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Peter Clark; Olivia Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future cardiology Volume: 7 ISSN: 1744-8298 ISO Abbreviation: Future Cardiol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101239345 Medline TA: Future Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 191-201 Citation Subset: IM |
Affiliation:
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Department of Transfusion Medicine, East of Scotland Blood Transfusion Centre, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK. peterclark@nhs.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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