| ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia. | |
| | |
MedLine Citation:
|
PMID: 23114529 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Although having a non-O blood type is now regarded as a risk factor for venous thromboembolism, the strength of this association is poorly defined, as is its interaction with inherited thrombophilia. MATERIALS AND METHODS: The prevalence of non-O blood group and inherited thrombophilia (deficiencies of natural anticoagulants, factor V Leiden and prothrombin G20210A mutation) was assessed in a series of 712 consecutive patients with proximal deep vein thrombosis (DVT) of the lower limbs who were referred to our Institution between 2004 and 2010, and in 712 age- and gender-matched healthy volunteers. Odds ratios (OR) of DVT and their 95% confidence intervals (CI) were computed for non-O group and thrombophilia, both separately and in combination. RESULTS: A non-O blood group was present in 492 cases and 358 controls (OR 2.21; 95% CI, 1.78 to 2.75). A thrombophilic abnormality was present in 237 cases and 105 controls (OR 2.82; 2.18 to 3.66). The combination of non-O group and thrombophilia was present in 152 cases and 51 controls (OR 7.06; 4.85 to 10.28). DISCUSSION: Having a non-O blood group is associated with an increased risk of proximal DVT of the lower limbs with or without pulmonary embolism. The addition of inherited thrombophilia increases the thrombotic risk conferred by non-O group alone by almost 3-fold. |
| | |
Authors:
|
Luca Spiezia; Elena Campello; Maria Bon; Tiziana Tison; Marta Milan; Paolo Simioni; Paolo Prandoni |
Related Documents
:
|
15126659 - Hemodynamic effects of clot entrapment in the trapease inferior vena cava filter. 23280789 - The blood-brain barrier in health and disease. 13706099 - Prothrombin time. determination by a whole blood micro-method for control of anticoagul... 23382169 - Heterogeneity and changes in inequality of malaria risk after introduction of insectici... 8123389 - Magnetic resonance imaging of extradural blood patches: appearances from 30 min to 18 h. 14512309 - In vitro and in vivo effects of tpa and pai-1 on blood vessel tone. 11903999 - Species differences in the blood content of the normal cellular isoform of prion protei... 19675069 - Dynamic changes in the direction of blood flow through the ductus arteriosus at birth. 801809 - Lactation: some cardiovascular and metabolic consequences, and the mechanisms of lactos... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
|
Title: Blood transfusion = Trasfusione del sangue Volume: - ISSN: 1723-2007 ISO Abbreviation: Blood Transfus Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101237479 Medline TA: Blood Transfus Country: - |
Other Details:
|
Languages: ENG Pagination: 1-5 Citation Subset: - |
Affiliation:
|
Department of Cardiothoracic and Vascular Sciences, University Hospital of Padua, Padua, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Real world usage of PCC to "rapidly" correct warfarin induced coagulopathy.
Next Document: A case of von Hippel-Lindau disease with juxtapapillary retinal capillary hemangioma and nutcracker ...