| ABL1 gene deletion without BCR/ABL1 rearrangement in a young adolescent with precursor B-cell acute lymphoblastic leukemia: clinical study and literature review. | |
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MedLine Citation:
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PMID: 20082857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Entire ABL1 gene deletion without BCR/ABL1 rearrangement is a rare phenomenon, with only four cases previously reported. Here we describe a fifth case of ABL1 deletion without BCR/ABL1 rearrangement in an adolescent patient with precursor B-cell lymphoblastic leukemia (B-ALL) and review the relevant literature. It is not clear how ABL1 deletion affects leukemogenesis; however, it is plausible that ABL1 deletion without BCR/ABL1 rearrangement is a rare but recurrent genetic abnormality in precursor B-ALL patients. Further studies are needed to evaluate the extent of the submicroscopic defects in chromosome 9 including ABL1 gene deletion, as well as treatment response and prognosis in long-term follow-up of such patients. |
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Authors:
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Min Jin Kim; Hoi Soo Yoon; Gayoung Lim; So Young Kim; Hee Joo Lee; Jin-Tae Suh; Juhie Lee; Woo-In Lee; Tae Sung Park |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 196 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-02-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Laboratory Medicine, Kyung Hee University School of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Fusion Proteins, bcr-abl / genetics* Gene Deletion* Gene Rearrangement* Humans In Situ Hybridization, Fluorescence Karyotyping Leukemia, B-Cell / genetics* Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Fusion Proteins, bcr-abl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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