| ABCs of Asthma. | |
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MedLine Citation:
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PMID: 18713655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asthma results from chronic airway inflammation involving a diversity of activated cells including mast cells, eosinophils, T-lymphocytes, neutrophils, macrophages, and epithelial cells. These cells release proinflammatory cytokine mediators that augment and regulate airway inflammation, leading to airway hyperresponsiveness responsible for the chronic asthma symptoms of dyspnea, wheezing, and chest tightness. It is hypothesized, but unproven, that inflammatory effects can lead to irreversible structural and functional airway changes. Early intervention with anti-inflammatory agents mitigates inflammatory changes, reverses airway obstruction, and may possibly prevent progression of airway remodeling. Current asthma guidelines recommend that initial management should be based on pretreatment assessments of asthma severity as determined by measures of clinical and spirometric impairment in individual patients; subsequent adjustments of pharmacotherapy and avoidance recommendations should be performed at regular follow-up visits and guided by frequent assessments of asthma control. Physicians and providers should continually educate asthmatic patients about proper use of asthma controller medications, avoidance of asthma triggers, and self-management of asthma exacerbations. |
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Authors:
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David I Bernstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical cornerstone Volume: 8 ISSN: 1098-3597 ISO Abbreviation: Clin Cornerstone Publication Date: 2008 |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9816002 Medline TA: Clin Cornerstone Country: United States |
Other Details:
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Languages: eng Pagination: 9-25 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Immunology & Allergy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. david.i.bernstein@uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Asthmatic Agents
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therapeutic use* Asthma / diagnosis, drug therapy*, etiology, physiopathology Diagnosis, Differential Humans Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Asthmatic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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