| AB-180 circulatory support system: summary of development and phase I clinical trial. | |
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MedLine Citation:
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PMID: 9804530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The AB-180 Circulatory Support System (AB-180 CSS; Cardiac Assist Technologies, Pittsburgh, PA) is a left ventricular assist system for investigational use in patients with postcardiotomy cardiogenic shock who are refractory to standard treatment with an intra-aortic balloon pump, pharmacologic treatment, or both. The intent of the AB-180 CSS is to provide temporary (up to 14 days) mechanical circulatory support until the heart recovers adequate mechanical function. The system consists of a small implantable centrifugal pump and a controller. A unique infusion system produces a hydrodynamic bearing between rotational and stationary components of the AB-180 CSS pump. This infusion system also provides a source of heparin for localized anticoagulation. Extensive bench and animal work has illustrated anticoagulation requirements, established operating guidelines, and demonstrated safety and efficacy. An investigational device exemption has been granted for a Phase I, five patient feasibility study at Allegheny General Hospital in Pittsburgh, Pennsylvania. To date, the pump has been implanted in one patient. The results from this first case are presented here. |
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Authors:
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W P Griffin; E B Savage; R E Clark; J J Pacella; G A Johnson; J A Magovern; G J Magovern |
Publication Detail:
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Type: Case Reports; Clinical Trial; Clinical Trial, Phase I; Journal Article |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 44 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 1998 Sep-Oct |
Date Detail:
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Created Date: 1999-02-23 Completed Date: 1999-02-23 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: M719-24 Citation Subset: IM |
Affiliation:
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Cardiac Assist Technologies, Pittsburgh, Pennsylvania 15238, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Feasibility Studies Heart-Assist Devices* Humans Male Middle Aged Prosthesis Design |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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