| The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis. | |
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MedLine Citation:
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PMID: 21148019 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Genetic and pharmacological inactivation of cannabinoid CB(1) receptors (CB(1)Rs) exacerbates disease course in experimental autoimmune encephalomyelitis, suggesting that CB(1)Rs might play a role in the neurodegenerative damage associated with multiple sclerosis (MS). Objectives: To see whether CNR1 gene polymorphism could influence disease progression in relapsing-remitting MS. Methods: The genotype of 350 patients for the number of AAT repeats was characterized and correlation studies were performed with measures of disease severity and progression. Results: MS patients with the homozygous genotype for long AAT repeats in the CNR1 gene had more severe disease and higher risk of progression. These subjects had significantly higher scores on both the progression index and the MS severity scale. Furthermore, the percentage of patients with MS functional composite score progression or Bayesian Risk Estimate for MS (BREMS) score ≥2 (considered at very high risk of secondary progression) was significantly higher in the AAT long group than in the short group, while the frequency of patients with BREMS score ≤-0.63 (very likely to remain progression-free) was not significantly different between the two groups, although lower in the long group. Finally, the frequency of patients prescribed a second-line treatment was significantly higher among subjects of the AAT long group, providing a further, indirect indication of higher disease severity. Conclusions: The results of the present investigation point to CB(1)R as an important modulator of disease severity in relapsing MS subjects. |
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Authors:
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Silvia Rossi; Fabio Buttari; Valeria Studer; Caterina Motta; Paolo Gravina; Maura Castelli; Vilma Mantovani; Valentina De Chiara; Alessandra Musella; Stefania Fiore; Silvia Masini; Giorgio Bernardi; Mauro Maccarrone; Sergio Bernardini; Diego Centonze |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-8 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: - ISSN: 1477-0970 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dipartimento di Neuroscienze, Università Tor Vergata/Fondazione Santa Lucia/Centro Europeo per la Ricerca sul Cervello (CERC), Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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