| AAL toxins, fumonisins (biology and chemistry) and host-specificity concepts. | |
| | |
MedLine Citation:
|
PMID: 1513374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The AAL toxins and the fumonisins (FB1 and FB2) are structurally related and produced respectively by Alternaria alternata f.sp. lycopersici and Fusarium moniliforme. AAL toxin is characterized as a host-specific toxin, toxic to tomato, whereas fumonisin B1 causes equine leukoencephalomalacia. FB1 and FB2 were biologically active in susceptible tomato tissue (Earlypak-7) and animal tissue culture (rat hepatoma H4TG and dog kidney MDCK). Conversely, AAL toxin was also active in the rat and dog tissue culture cells. Both fungi produce toxin/s in culture that causes death in rats; these toxins are other than AAL and fumonisin. The peracetylated derivatives of AAL and FB1 are biologically inactive in both the tomato bioassay and the animal tissue culture systems. Acetylation of the amine renders AAL inactive. The hydrolysis product of AAL (phentolamine) is toxic to the susceptible tomato line whereas the phentolamine of fumonisin is not. AAL and FB1 can be analyzed by Continuous Flow Fast Atom Bombardment (CFFAB) and Ionspray Mass Spectrometry (ISM), both sensitive to the picomole range. The N-acetyl of the TFA hydrolysis product of AAL and FB1 is determined by comparing the fragment ions at m/z 86 and 140 for FB1 and 72 and 126 for AAL. |
| | |
Authors:
|
C J Mirocha; D G Gilchrist; W T Shier; H K Abbas; Y Wen; R F Vesonder |
Related Documents
:
|
8394504 - Changes in the glucose-6-phosphatase complex in hepatomas. 6891904 - Anticarcinogenic actions of water-soluble and alcohol-insoluble fractions from culture ... 209014 - The serine protease from rat liver and hepatoma 8999. location and role in mitochondria... 5085644 - Studies of the ethylation of rat liver transfer ribonucleic acid after administration o... 8570864 - Mechanism of sex-related differences in nephrotoxicity of 1.2-dichloropropane in rats. 1298614 - In vivo effect of cadmium chloride on intestinal colonization of rats by campylobacter ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Mycopathologia Volume: 117 ISSN: 0301-486X ISO Abbreviation: Mycopathologia Publication Date: 1992 Feb |
Date Detail:
|
Created Date: 1992-10-01 Completed Date: 1992-10-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7505689 Medline TA: Mycopathologia Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 47-56 Citation Subset: IM |
Affiliation:
|
Department of Plant Pathology, University of Minnesota, St. Paul 55108. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alternaria* Animals Cell Line Dogs Encephalomalacia / chemically induced, veterinary Female Fumonisins* Fusarium* Horse Diseases / chemically induced Horses Mass Spectrometry Mice Mycotoxins / biosynthesis, chemistry, toxicity* Rats Species Specificity Spectrometry, Mass, Fast Atom Bombardment Sphingosine* Structure-Activity Relationship Swine |
| Chemical | |
Reg. No./Substance:
|
0/Alternaria alternata pathotoxin TA; 0/Fumonisins; 0/Mycotoxins; 116355-83-0/fumonisin B1; 116355-84-1/fumonisin B2; 123-78-4/Sphingosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fumonisin B1 production and vegetative compatibility of strains from Gibberella fujikuroi mating pop...
Next Document: In vitro toxicology of fumonisins and the mechanistic implications.