| AA-Amyloid is cleared by endogenous immunological mechanisms. | |
| | |
MedLine Citation:
|
PMID: 22900541 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective: AA amyloidosis is a complication to longstanding inflammatory diseases, but reduction of amyloid mass has been reported as the inflammation ceases. Not much is known about the endogenous factors that contribute to this amyloid resolution. Herein, we describe the dynamics of amyloid degradation and resolution in experimental murine AA-amyloidosis. Methods: AA-amyloidosis was induced in mice with injections of amyloid enhancing factor (AEF) and by inflammation induced with injections of silver nitrate. Resolution of amyloid deposits was monitored over time. Results: Virtually all amyloid was cleared within 34 weeks. Using the ELISA-technique, antibodies directed against protein AA were detected in animals during amyloid clearance phase and macrophages were shown to internalize amyloid. Also, passive immunization with an amyloid specific monoclonal antibody, produced by a B-cell clone recovered from an animal with advanced AA-amyloidosis, reduced amyloid development in murine AA-amyloidosis. Conclusion: Immunoglobulins co-localize with amyloid deposits and can contribute to amyloid degradation by Fc-receptor mediated phagocytosis, and should be considered key players in the degradation process. |
| | |
Authors:
|
Sofia N Nyström; Gunilla T Westermark |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 19 ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-08-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433802 Medline TA: Amyloid Country: England |
Other Details:
|
Languages: eng Pagination: 138-45 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University , Linköping , Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microscale patterning of thermoplastic polymer surfaces by selective solvent swelling.
Next Document: Stable, compact, bright biofunctional quantum dots with improved peptide coating.