Document Detail

A70104 and food intake in pigs: implication for the CCK 'satiety' hypothesis.
MedLine Citation:
PMID:  8513125     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to determine whether CCK released from the small intestine during a meal acts as a satiety factor. The effects of the novel CCKA antagonist A70104 (50-200 micrograms kg-1, i.v.) were investigated on operant food intake in 4 h food-deprived pigs. None of the doses used had any significant effects on the amount of food consumed by the animals over the 2 h measurement period. However, pretreatment of the pigs with A70104 (100 micrograms kg-1) did block the inhibitory effect of exogenous CCK (1 microgram kg-1, i.v.) on operant feeding. These results thus question the validity of the hypothesis that endogenous peripheral CCK acts as a satiety factor.
I S Ebenezer; R F Parrott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  4     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-22     Completed Date:  1993-07-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  IM    
AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
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MeSH Terms
Cholecystokinin / antagonists & inhibitors*,  pharmacology
Conditioning, Operant / drug effects
Eating / drug effects*
Quinolines / pharmacology*
Receptors, Cholecystokinin / antagonists & inhibitors*
Reinforcement (Psychology)
Satiety Response / drug effects*
Reg. No./Substance:
0/Quinolines; 0/Receptors, Cholecystokinin; 119295-94-2/A 65186; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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