Document Detail


A70104 and food intake in pigs: implication for the CCK 'satiety' hypothesis.
MedLine Citation:
PMID:  8513125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to determine whether CCK released from the small intestine during a meal acts as a satiety factor. The effects of the novel CCKA antagonist A70104 (50-200 micrograms kg-1, i.v.) were investigated on operant food intake in 4 h food-deprived pigs. None of the doses used had any significant effects on the amount of food consumed by the animals over the 2 h measurement period. However, pretreatment of the pigs with A70104 (100 micrograms kg-1) did block the inhibitory effect of exogenous CCK (1 microgram kg-1, i.v.) on operant feeding. These results thus question the validity of the hypothesis that endogenous peripheral CCK acts as a satiety factor.
Authors:
I S Ebenezer; R F Parrott
Related Documents :
8185155 - Integration of postprandial function in the proximal gastrointestinal tract. role of cc...
6330485 - The inhibition of tail-pinch-induced food intake by cholecystokinin octapeptides and th...
16119485 - Patient-controlled epidural analgesia following combined spinal-epidural analgesia in l...
4059385 - Effects of vagotomy on satiety induced by gastrointestinal hormones in the rat.
21683485 - Muscle protein synthesis in cancer patients can be stimulated with a specially formulat...
12669015 - Use of the think-aloud method to identify factors influencing purchase of bread and cer...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  4     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-22     Completed Date:  1993-07-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  IM    
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cholecystokinin / antagonists & inhibitors*,  pharmacology
Conditioning, Operant / drug effects
Eating / drug effects*
Quinolines / pharmacology*
Receptors, Cholecystokinin / antagonists & inhibitors*
Reinforcement (Psychology)
Satiety Response / drug effects*
Swine
Chemical
Reg. No./Substance:
0/Quinolines; 0/Receptors, Cholecystokinin; 119295-94-2/A 65186; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D28k.
Next Document:  Effect of hypothyroidism on rat peripheral nervous system.