Document Detail


A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
MedLine Citation:
PMID:  2671814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.
Authors:
B T Hyman; G W Van Hoesen; K Beyreuther; C L Masters
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  101     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-25     Completed Date:  1989-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  352-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism*,  pathology
Amyloid / metabolism*
Amyloid beta-Protein
Humans
Immunohistochemistry
Neurofibrils / metabolism*,  pathology
Grant Support
ID/Acronym/Agency:
IT32N507294//PHS HHS; NS 14911/NS/NINDS NIH HHS; P0 NS 19632/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid; 0/Amyloid beta-Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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