| A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles. | |
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MedLine Citation:
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PMID: 2671814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques. |
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Authors:
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B T Hyman; G W Van Hoesen; K Beyreuther; C L Masters |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 101 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-09-25 Completed Date: 1989-09-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 352-5 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Iowa College of Medicine, Iowa City 52242. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism*,
pathology Amyloid / metabolism* Amyloid beta-Protein Humans Immunohistochemistry Neurofibrils / metabolism*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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IT32N507294//PHS HHS; NS 14911/NS/NINDS NIH HHS; P0 NS 19632/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/Amyloid beta-Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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