Document Detail

A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.
MedLine Citation:
PMID:  22743606     Owner:  NLM     Status:  MEDLINE    
The present study examined the effect of two A(2A) adenosine receptor (AR) agonists, CGS 21680 and VT 7, on high-palatability food (HPF) intake in a model of binge eating in sated rats and on low-palatability food (LPF) intake in food-deprived rats. Binge eating was induced in female rats by three 8-day cycles of food restriction/refeeding, followed by acute stress. Two groups of rats were used: NR+NS rats normally fed and not stressed and R+S rats exposed to cycles of food restriction/refeeding and then stressed. R+S rats had higher intake of HPF than the NR+NS controls. The two A(2A)AR agonists were tested at doses of 0.1 and 0.05 mg/kg intraperitoneally; VT 7 did not modify locomotor activity at either dose, whereas CGS 21680 only slightly reduced it at the higher dose tested. The injection of 0.1 mg/kg of both agonists markedly reduced HPF intake both in R+S and in NR+NS rats. The dose of 0.05 mg/kg was inactive. CGS 21680 and VT 7, 0.1 mg/kg, also reduced the standard LPF intake in 24 h food-deprived rats; however, they did not reduce water intake, indicating that their effect on food intake is selective. The dose of 0.05 mg/kg was inactive. Thus, A(2A)AR agonists exert a rather general effect on food intake, inhibiting both HPF intake in sated rats and LPF intake in food-deprived rats. They may potentially be useful pharmacological agents to control binge-related eating disorders and to reduce food overconsumption associated with obesity.
Maria V Micioni Di Bonaventura; Carlo Cifani; Catia Lambertucci; Rosaria Volpini; Gloria Cristalli; Maurizio Massi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  23     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-17     Revised Date:  2014-04-26    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-74     Citation Subset:  IM    
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MeSH Terms
Adenosine / administration & dosage,  analogs & derivatives*,  therapeutic use
Adenosine A2 Receptor Agonists / administration & dosage,  therapeutic use*
Appetite Depressants / administration & dosage,  therapeutic use*
Appetite Regulation / drug effects
Behavior, Animal / drug effects
Binge-Eating Disorder / drug therapy*
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Therapy, Combination
Energy Intake / drug effects
Feeding Behavior / drug effects*
Food Preferences
Nerve Tissue Proteins / antagonists & inhibitors,  metabolism
Phenethylamines / administration & dosage,  therapeutic use*
Rats, Sprague-Dawley
Receptor, Adenosine A2A / chemistry,  metabolism*
Satiety Response / drug effects
Thionucleosides / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/5'-N-ethylcarboxamido-2-(2-phenethylthio)adenosine; 0/Adenosine A2 Receptor Agonists; 0/Appetite Depressants; 0/Nerve Tissue Proteins; 0/Phenethylamines; 0/Receptor, Adenosine A2A; 0/Thionucleosides; 120225-54-9/2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; K72T3FS567/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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