Document Detail


A20: linking a complex regulator of ubiquitylation to immunity and human disease.
MedLine Citation:
PMID:  23059429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts multiple intracellular signalling cascades. Recent studies in three general areas have converged to highlight the clinical and biological importance of A20. First, human genetic studies have strongly linked polymorphisms and mutations in the gene encoding A20 to inflammatory, autoimmune and malignant diseases. Second, studies in gene-targeted mice have revealed that A20 regulates multiple immune cell functions and prevents experimental diseases that closely mimic human conditions. Third, biochemical studies have unveiled complex mechanisms by which A20 regulates ubiquitin-dependent nuclear factor-κB and cell-survival signals. Taken together, these studies are revealing the importance of A20-mediated regulation of ubiquitin-dependent signalling in human disease.
Authors:
Averil Ma; Barbara A Malynn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-12
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  12     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-04     Revised Date:  2014-07-24    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  774-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / genetics,  metabolism*
DNA-Binding Proteins / genetics,  metabolism*
Humans
Inflammation / immunology,  metabolism
Inflammation Mediators
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Mice
NF-kappa B / immunology,  metabolism*
Neoplasms / metabolism*
Nuclear Proteins / genetics,  metabolism*
Signal Transduction*
Ubiquitination
Grant Support
ID/Acronym/Agency:
R01 DK071939/DK/NIDDK NIH HHS; R01 DK095693/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Inflammation Mediators; 0/Intracellular Signaling Peptides and Proteins; 0/NF-kappa B; 0/Nuclear Proteins; EC 6.3.2.19/TNFAIP3 protein, human
Comments/Corrections

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