| A20: from ubiquitin editing to tumour suppression. | |
| | |
MedLine Citation:
|
PMID: 20383180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Clinicians have suspected for hundreds of years that chronic activation of the immune system contributes to the development of cancer. However, the molecular mechanisms that mediate this precarious interplay are only now being elucidated. Recent reports have identified A20 as a crucial tumour suppressor in various lymphomas. A20 is a ubiquitin-editing enzyme that attenuates the activity of proximal signalling complexes at pro-inflammatory receptors. In this Review we summarize the evidence linking chronic inflammation with tumorigenesis and consider how A20 modulates inflammatory signalling cascades, thereby providing a mechanism to explain how deregulation of ubiquitylation can promote tumorigenesis. |
| | |
Authors:
|
Sarah G Hymowitz; Ingrid E Wertz |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-04-12 |
Journal Detail:
|
Title: Nature reviews. Cancer Volume: 10 ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-23 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: England |
Other Details:
|
Languages: eng Pagination: 332-41 Citation Subset: IM |
Affiliation:
|
Department of Structural Biology, Genentech, Inc.1 DNA Way, M/S 40, South San Francisco, CA 94080, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Genes, Tumor Suppressor Humans Inflammation / genetics, metabolism Intracellular Signaling Peptides and Proteins / metabolism* NF-kappa B / genetics, metabolism Neoplasms / genetics, metabolism* Nuclear Proteins / metabolism* Signal Transduction / physiology* Ubiquitin / metabolism* Ubiquitination / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Intracellular Signaling Peptides and Proteins; 0/NF-kappa B; 0/Nuclear Proteins; 0/Ubiquitin; EC 6.3.2.19/TNFAIP3 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer.
Next Document: Treatment options for male stress urinary incontinence.