Document Detail

A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma.
MedLine Citation:
PMID:  22585859     Owner:  NLM     Status:  MEDLINE    
SIGNIFICANCE: These results identify A20 E3 ligase as a therapeutic target whose inhibition can overcome TNF-related apoptosis-inducing ligand resistance in glioblastoma and thus have an impact on ongoing clinical trials of TNF-related apoptosis-inducing ligand-targeted combination cancer therapies.
Anita C Bellail; Jeffrey J Olson; Xiaolu Yang; Zhijian J Chen; Chunhai Hao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-24
Journal Detail:
Title:  Cancer discovery     Volume:  2     ISSN:  2159-8290     ISO Abbreviation:  Cancer Discov     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-05-15     Completed Date:  2013-01-15     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  101561693     Medline TA:  Cancer Discov     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-55     Citation Subset:  IM    
Copyright Information:
©2012 AACR.
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MeSH Terms
Apoptosis / physiology
Apoptosis Regulatory Proteins / metabolism
Brain Neoplasms / metabolism*,  pathology
Caspase 8 / metabolism*
Cell Line, Tumor
DNA-Binding Proteins / metabolism*
Glioblastoma / metabolism*,  pathology
HEK293 Cells
Intracellular Signaling Peptides and Proteins / metabolism*
Nuclear Proteins / metabolism*
Receptor-Interacting Protein Serine-Threonine Kinases / metabolism*
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand / metabolism*,  pharmacology
Ubiquitin / metabolism
Ubiquitin-Protein Ligases / metabolism*
Grant Support
CA129687/CA/NCI NIH HHS; R01 CA129687/CA/NCI NIH HHS; R01 CA129687-01A2/CA/NCI NIH HHS; R01 CA129687-02/CA/NCI NIH HHS; R01 CA129687-03/CA/NCI NIH HHS; R01 CA129687-04/CA/NCI NIH HHS
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/DNA-Binding Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/TNF-Related Apoptosis-Inducing Ligand; 0/TNFSF10 protein, human; 0/Ubiquitin; EC protein, human; EC Protein Serine-Threonine Kinases; EC 3.4.22.-/Caspase 8; EC protein, human; EC Ligases
Comment In:
Cancer Discov. 2012 Feb;2(2):112-4   [PMID:  22585854 ]

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