| A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density in Japanese male workers. | |
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MedLine Citation:
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PMID: 21432225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Both genetic and lifestyle factors have been shown to influence bone mineral density (BMD). We investigated the correlations between BMD and low-density lipoprotein receptor-related protein 5 (LRP5) A1330V (rs3736228) polymorphism, exercise, smoking, and alcohol intake in Japanese male workers. METHODS: The subjects were 829 male employees (aged 20-59 years) of a large-scale integrated manufacturing facility in Japan. BMD was measured at the nondominant radius by dual-energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire at the same time, and genomic DNA was isolated from peripheral leukocytes. RESULTS: Mean ± standard deviation (SD) BMD was 0.557 ± 0.059 g/cm(2). The genotype frequencies of LRP5 gene polymorphism were 51, 42, and 7% for AA, AV, and VV, respectively. Analysis of variance and post hoc Tukey test indicated that mean BMD was significantly lower in subjects with VV genotype than in those with AA genotype (0.540 ± 0.048 versus 0.562 ± 0.062 g/cm(2)). According to multiple linear regression analysis, LRP5 A1330V polymorphism was an independent determinant of BMD, after adjusting for age, body mass index (BMI), and lifestyle variables. Exercise (past or current) also influenced BMD. CONCLUSIONS: These findings suggest that LRP5 A1330V polymorphism and exercise may influence BMD in Japanese male workers. |
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Authors:
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Yayoi Funakoshi; Hisamitsu Omori; Hironori Yada; Takahiko Katoh |
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Publication Detail:
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Type: Journal Article Date: 2010-08-11 |
Journal Detail:
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Title: Environmental health and preventive medicine Volume: 16 ISSN: 1347-4715 ISO Abbreviation: Environ Health Prev Med Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-24 Completed Date: 2011-07-28 Revised Date: 2012-03-01 |
Medline Journal Info:
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Nlm Unique ID: 9609642 Medline TA: Environ Health Prev Med Country: Japan |
Other Details:
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Languages: eng Pagination: 106-12 Citation Subset: IM |
Affiliation:
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Department of Public Health, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjou, Kumamoto, 860-8556, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult Aging Body Mass Index Bone Density* Cross-Sectional Studies Exercise* Genetic Markers Genetic Predisposition to Disease Genotype Humans Japan LDL-Receptor Related Proteins / blood, genetics* Leukocytes / chemistry Life Style Linear Models Low Density Lipoprotein Receptor-Related Protein-5 Male Middle Aged Osteoporosis / diagnosis*, genetics, prevention & control Polymorphism, Genetic* Questionnaires Radius / radiography Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/LDL-Receptor Related Proteins; 0/LRP5 protein, human; 0/Low Density Lipoprotein Receptor-Related Protein-5 |
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